MAN1A1

Description		mannosidase alpha class 1A member 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Protein Binding Mannosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation ERAD Pathway Protein Targeting To ER Golgi Apparatus Mannose Trimming Mannose Trimming Involved In Glycoprotein ERAD Pathway
Pathways		Intra-Golgi traffic Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2
Drugs
Diseases
GWAS		Adult body size ( 32376654) Fasting glucose ( 33381925) Metabolite levels ( 23823483) Neonatal white matter microstructure ( 33009551) Spontaneous preterm birth (preterm birth) ( 25599974) Weight ( 28552196)
Novel Interacting Genes		2 novel interacting genes: CFTR PRDM1
Interacting Genes		2 interacting genes: CFTR PRDM1
Entrez ID		4121
HPRD ID		05066
Ensembl ID		ENSG00000111885
Uniprot IDs		P33908
PDB IDs
Enriched GO Terms of Interacting Partners?		Sebum Secreting Cell Proliferation Regulation Of Extrathymic T Cell Differentiation Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Regulation Of NK T Cell Differentiation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Retinal Bipolar Neuron Differentiation Maternal Placenta Development Intestinal Epithelial Cell Development Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Trophoblast Giant Cell Differentiation Regulation Of Natural Killer Cell Differentiation Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Columnar/cuboidal Epithelial Cell Development Cellular Response To Forskolin Histone Methyltransferase Binding Glutamatergic Neuron Differentiation Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Heart Valve Development Developmental Process Involved In Reproduction Embryonic Placenta Development Cell Differentiation Involved In Embryonic Placenta Development Water Transport Bicarbonate Transport Coronary Vasculature Development Multicellular Organismal-level Water Homeostasis Eye Photoreceptor Cell Development Aorta Development Maternal Process Involved In Female Pregnancy Ventricular Septum Development Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding
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