LTK

Description		leukocyte receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity
	Biological Process	Protein Phosphorylation Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Population Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Retinoic Acid
Pathways		Signaling by LTK
Drugs		Fostamatinib
Diseases
GWAS		High density lipoprotein cholesterol levels ( 31928498) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lymphocyte percentage of white cells ( 32888494) Type 2 diabetes ( 30297969) Urinary albumin excretion (no hypertensive medication) ( 30220432)
Novel Interacting Genes		6 novel interacting genes: CBL DUSP6 MTMR14 PIK3C2B PTPN1 SHC1
Interacting Genes		6 interacting genes: CBL DUSP6 MTMR14 PIK3C2B PTPN1 SHC1
Entrez ID		4058
HPRD ID		01052
Ensembl ID		ENSG00000062524
Uniprot IDs		P29376
PDB IDs		7NX0 7NX1
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Receptor Tyrosine Kinase Binding Response To Growth Factor Response To Platelet-derived Growth Factor Cellular Response To Platelet-derived Growth Factor Stimulus Peptidyl-tyrosine Dephosphorylation Insulin Receptor Binding Cellular Response To Growth Factor Stimulus Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Phosphotyrosine Residue Binding Negative Regulation Of ERK1 And ERK2 Cascade Insulin Receptor Signaling Pathway Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Response To Nutrient Levels Protein Tyrosine Phosphatase Activity Phosphate-containing Compound Metabolic Process Phosphatidylinositol Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Shc-EGFR Complex Cellular Response To Hypoxia Cytosol Phosphoprotein Phosphatase Activity Dephosphorylation Phosphatidylinositol Metabolic Process Cellular Response To Decreased Oxygen Levels Response To Stress Regulation Of MAPK Cascade Cellular Response To Oxygen Levels Regulation Of Rap Protein Signal Transduction Negative Regulation Of MAPK Cascade Macroautophagy Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Insulin Receptor Recycling Positive Regulation Of Cell Proliferation In Bone Marrow Epidermal Growth Factor Binding Intracellular Signal Transduction Glycerophospholipid Biosynthetic Process Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Regulation Of Cell Proliferation In Bone Marrow Ubiquitin-dependent Endocytosis MAP Kinase Tyrosine Phosphatase Activity Lipid Kinase Activity Sorting Endosome Neurotrophin TRKA Receptor Binding Regulation Of Intracellular Signal Transduction
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