LTBR

Description		lymphotoxin beta receptor
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Apoptotic Process Immune Response Signal Transduction Myeloid Dendritic Cell Differentiation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade Hematopoietic Or Lymphoid Organ Development Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Aspartate aminotransferase levels ( 33547301) Basophil count ( 32888494) Celiac disease ( 31591516) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 26192919 28067908) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244 24076602) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Primary biliary cirrhosis ( 22961000) Tonsillectomy ( 28928442 27182965) White blood cell count ( 32888494)
Novel Interacting Genes		15 novel interacting genes: BIRC2 DIABLO HES1 LTA LTB MTNR1B RABAC1 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRIM37 ZMYND11
Interacting Genes		15 interacting genes: BIRC2 DIABLO HES1 LTA LTB MTNR1B RABAC1 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRIM37 ZMYND11
Entrez ID		4055
HPRD ID		02988
Ensembl ID		ENSG00000111321
Uniprot IDs		P36941
PDB IDs		1RF3 4MXW
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Regulation Of Canonical NF-kappaB Signal Transduction Thioesterase Binding CD40 Receptor Complex Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Signaling Adaptor Activity Apoptotic Process Cell Death Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Side Of Plasma Membrane Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Apoptotic Signaling Pathway Ubiquitin Protein Ligase Activity Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Cytokine-mediated Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Ubiquitin-protein Transferase Activity Positive Regulation Of Apoptotic Process Zinc Ion Binding Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Lymph Node Development Positive Regulation Of DNA-binding Transcription Factor Activity Programmed Necrotic Cell Death Signaling Cell Communication Response To Other Organism Positive Regulation Of Protein Modification Process Positive Regulation Of Multicellular Organismal Process Regulation Of JNK Cascade
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