LRP4

Description		LDL receptor related protein 4
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Postsynaptic Density Membrane Dendrite Neuromuscular Junction Neuronal Cell Body Plasma Membrane Raft Synapse Synaptic Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Coreceptor Activity Receptor Tyrosine Kinase Binding Apolipoprotein Binding Protein Homodimerization Activity Scaffold Protein Binding
	Biological Process	Kidney Development Hair Follicle Development Endocytosis Enzyme-linked Receptor Protein Signaling Pathway Intracellular Protein Localization Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Ossification Embryonic Limb Morphogenesis Positive Regulation Of Rac Protein Signal Transduction Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Receptor Clustering Generation Of Neurons System Development Dendrite Morphogenesis Negative Regulation Of Axonogenesis Synapse Organization Synaptic Assembly At Neuromuscular Junction Limb Development Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Canonical Wnt Signaling Pathway Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Regulation Of Postsynapse Assembly Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Presynaptic Membrane Organization Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways		ECM proteoglycans
Drugs
Diseases		Cenani-Lenz syndactyly syndrome
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Bone mineral density (hip) ( 19079262) D-dimer levels ( 21502573) General risk tolerance (MTAG) ( 30643258) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 28334899) Heel bone mineral density ( 28869591 30598549) Hip index ( 34021172) Intraocular pressure ( 29617998) Mood instability ( 31168069) Pre-treatment viral load in HIV-1 infection ( 31219150) Reaction time ( 29844566) Systolic blood pressure ( 30224653) Urate levels ( 31578528) Venous thromboembolism ( 31420334)
Novel Interacting Genes		5 novel interacting genes: DSCR9 DYRK1A LCOR OGT WHRN
Interacting Genes		5 interacting genes: DSCR9 DYRK1A LCOR OGT WHRN
Entrez ID		4038
HPRD ID		18517
Ensembl ID		ENSG00000134569
Uniprot IDs		O75096
PDB IDs		8S9P
Enriched GO Terms of Interacting Partners?		Actin Filament Histone H3T45 Kinase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Protein-containing Complex Assembly Circadian Rhythm Cerebellar Purkinje Cell Layer Formation Paranodal Junction Maintenance Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Stereocilia Ankle Link Stereocilia Ankle Link Complex USH2 Complex Periciliary Membrane Compartment Carbon Catabolite Regulation Of Transcription Rhythmic Process Regulation Of Heterochromatin Formation Regulation Of Transcription By Glucose RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Positive Regulation Of Gene Expression Neurofilament NSL Complex Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Stereocilium Bundle
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