LOXL1

Description		lysyl oxidase like 1
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix
	Molecular Function	Protein-lysine 6-oxidase Activity Copper Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Metal Ion Binding
	Biological Process	Protein Deamination Collagen Fibril Organization Response To Lipopolysaccharide Aorta Development
Pathways		Elastic fibre formation Crosslinking of collagen fibrils
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adult body size ( 32376654) Aortic root size ( 19584346) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Coronary artery disease ( 33020668 29212778) Diverticular disease ( 30177863) Exfoliation glaucoma or exfoliation syndrome ( 24938310) Exfoliation syndrome ( 25706626) Glaucoma (exfoliation) ( 17690259) Glaucoma (primary open-angle) ( 33627673) Hand grip strength ( 29691431) Height ( 28552196 23563607 31562340) Hip circumference adjusted for BMI ( 34021172) Joint mobility (Beighton score) ( 27182965) Pelvic organ prolapse ( 32184442) Pseudoexfoliation syndrome ( 29278698) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 28448500 25673412) Waist-hip index ( 34021172) Youthful appearance (self-reported) ( 32339537)
Novel Interacting Genes		4 novel interacting genes: ATXN1 ELN FBLN5 MFGE8
Interacting Genes		4 interacting genes: ATXN1 ELN FBLN5 MFGE8
Entrez ID		4016
HPRD ID		08861
Ensembl ID		ENSG00000129038
Uniprot IDs		H3BUV8 Q08397
PDB IDs
Enriched GO Terms of Interacting Partners?		Elastic Fiber Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Assembly Extracellular Matrix Extracellular Matrix Structural Constituent Intramembranous Bone Growth Integrin Binding Extracellular Structure Organization Extracellular Matrix Organization POZ Domain Binding Regulation Of Removal Of Superoxide Radicals Poly(G) Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Response To Reactive Oxygen Species Elastic Fiber Assembly Nuclear Inclusion Body Positive Regulation Of Osteoblast Proliferation Regulation Of Cell Population Proliferation Respiratory Gaseous Exchange By Respiratory System Extracellular Region Extracellular Matrix Binding Stress Fiber Assembly Supramolecular Fiber Organization Contractile Actin Filament Bundle Assembly Acrosomal Membrane Apoptotic Cell Clearance Poly(U) RNA Binding Positive Regulation Of Glial Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Response To Oxidative Stress Regulation Of Osteoblast Proliferation Regulation Of Cellular Response To Oxidative Stress Protein Localization To Cell Surface Regulation Of Superoxide Metabolic Process Bone Growth
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