SHC4

Description		SHC adaptor protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse Postsynaptic Membrane
	Molecular Function	Protein Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding
	Biological Process	Apoptotic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Intracellular Signal Transduction Stem Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Cadmium levels ( 26025379) Eating disorders ( 22911880) Iris color (b* coordinate) ( 30895295) Major depressive disorder ( 21621269 29187746) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Skin aging measurement ( 31522824)
Novel Interacting Genes		10 novel interacting genes: AR EGFR ERBB2 ERBB3 ERBB4 GRB2 KIT MET RET TEK
Interacting Genes		10 interacting genes: AR EGFR ERBB2 ERBB3 ERBB4 GRB2 KIT MET RET TEK
Entrez ID		399694
HPRD ID		15289
Ensembl ID		ENSG00000185634
Uniprot IDs		F5H5M1 Q6S5L8
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Basal Plasma Membrane Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Protein Kinase Activity Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction ERBB Signaling Pathway ERBB2 Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Animal Organ Development Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Neuron Differentiation Cellular Developmental Process Regulation Of Epithelial Cell Proliferation Regulation Of Signal Transduction ATP Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Population Proliferation Basolateral Plasma Membrane Schwann Cell Development Cell Differentiation Positive Regulation Of Signal Transduction ERBB3:ERBB2 Complex Nucleotide Binding Transferase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Multicellular Organismal Process Plasma Membrane Tissue Morphogenesis Growth Factor Binding Epithelial Cell Proliferation Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Apoptotic Process Intracellular Signaling Cassette
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