FLG2

Description		filaggrin 2
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Nucleus Cytoplasm Keratohyalin Granule Tertiary Granule Lumen
	Molecular Function	Structural Molecule Activity Calcium Ion Binding Metal Ion Binding Transition Metal Ion Binding
	Biological Process	Cell Adhesion Epidermis Morphogenesis Establishment Of Skin Barrier
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Eating disorders ( 23568457) Systemic sclerosis ( 33069728)
Novel Interacting Genes		3 novel interacting genes: HSP90AA1 USP7 WEE2-AS1
Interacting Genes		3 interacting genes: HSP90AA1 USP7 WEE2-AS1
Entrez ID		388698
HPRD ID		11815
Ensembl ID		ENSG00000143520
Uniprot IDs		Q5D862
PDB IDs
Enriched GO Terms of Interacting Partners?		Rho GDP-dissociation Inhibitor Binding CTP Binding Protein Stabilization DATP Binding Neurofibrillary Tangle Assembly Regulation Of Intracellular Transport Protein-RNA Complex Assembly UTP Binding Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Sulfonylurea Receptor Binding Symbiont-mediated Disruption Of Host Cell PML Body Pre-mRNA 5'-splice Site Binding Chaperone-mediated Autophagy Sperm Mitochondrial Sheath Nitric-oxide Synthase Regulator Activity Regulation Of Protein Catabolic Process Regulation Of Protein Stability Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding Telomerase Holoenzyme Complex Assembly Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Retrograde Transport, Endosome To Golgi MRNA 5'-splice Site Recognition Positive Regulation Of Cardiac Muscle Contraction Inclusion Body Assembly Monoubiquitinated Protein Deubiquitination Positive Regulation Of Cell Size Protein Unfolding DNA Alkylation Repair Transcription-coupled Nucleotide-excision Repair Regulation Of DNA Metabolic Process Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Striated Muscle Contraction Striated Muscle Cell Apoptotic Process Regulation Of Telomere Capping Regulation Of Cellular Localization Cellular Component Assembly Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Establishment Of Protein Localization Enzyme-substrate Adaptor Activity Endocytic Vesicle Lumen Positive Regulation Of Catabolic Process Response To Salt Stress Muscle Cell Apoptotic Process Negative Regulation Of Gluconeogenesis K48-linked Deubiquitinase Activity U1 SnRNP
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