THEMIS

Description		thymocyte selection associated
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cell-cell Junction COP9 Signalosome
	Molecular Function	Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Positive T Cell Selection Negative T Cell Selection T Cell Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Asthma ( 31619474 31959851 34103634) Celiac disease ( 20190752 25920553) Crohn's disease ( 28067908) Heel bone mineral density x serum urate levels interaction ( 34046847) Hepcidin/ferritin ratio ( 27846281) Multiple sclerosis ( 21833088 31604244) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Post bronchodilator FEV1/FVC ratio ( 26634245) Recalcitrant atopic dermatitis ( 25935106)
Novel Interacting Genes		1 novel interacting genes: PRMT6
Interacting Genes		1 interacting genes: PRMT6
Entrez ID		387357
HPRD ID		16662
Ensembl ID		ENSG00000172673
Uniprot IDs		Q8N1K5
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Histone H3 Methyltransferase Activity Histone Methyltransferase Activity Base-excision Repair Regulation Of Megakaryocyte Differentiation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Senescence Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Mitochondrion Organization Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Proteolysis Histone Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Methyltransferase Activity
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