KRT10

Description		keratin 10
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Cell Surface Membrane Keratin Filament Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis Protein Heterodimerization Activity
	Biological Process	Morphogenesis Of An Epithelium Peptide Cross-linking Keratinocyte Differentiation Intermediate Filament Organization Positive Regulation Of Epidermis Development Protein Heterotetramerization
Pathways		Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs		Zinc Copper Zinc acetate
Diseases		Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE) Ichthyosis with confetti; Congenital reticular ichthyosiform erythroderma; Ichthyosis variegata
GWAS		Glucose homeostasis traits ( 25524916)
Novel Interacting Genes		10 novel interacting genes: AKT1 ESR1 EVPL GLE1 OGT PRKCZ RNF26 SIRPA SMAD3 SNAPIN
Interacting Genes		10 interacting genes: AKT1 ESR1 EVPL GLE1 OGT PRKCZ RNF26 SIRPA SMAD3 SNAPIN
Entrez ID		3858
HPRD ID		01021
Ensembl ID		ENSG00000186395
Uniprot IDs		A0A1B0GVI3 P13645
PDB IDs		3ASW 4F1Z 4ZRY 6E2J 6EC0 6UUI
Enriched GO Terms of Interacting Partners?		Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Defense Response Cellular Response To Oxygen-containing Compound Nitric-oxide Synthase Regulator Activity Intracellular Protein Localization Response To Hormone Response To Peptide Hormone Ciliary Basal Body Negative Regulation Of Cellular Component Organization Regulation Of Immune System Process Regulation Of Immune Response Response To Insulin Negative Regulation Of MiRNA Transcription Organelle Organization Positive Regulation Of Cell Adhesion Regulation Of Cellular Localization Maternal Process Involved In Female Pregnancy 14-3-3 Protein Binding Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Gene Expression Phosphatidylinositol-3,4,5-trisphosphate Binding Protein K11-linked Ubiquitination Protein Metabolic Process Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Transcription Corepressor Binding Positive Regulation Of T Cell Activation Transcription Coactivator Binding Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Defense Response Regulation Of TRNA Methylation Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Late Endosome To Lysosome Transport Cellular Response To Glucose Stimulus TORC1 Signaling Negative Regulation Of Signal Transduction Apoptotic Mitochondrial Changes Positive Regulation Of TORC1 Signaling Protein Maturation Regulation Of Cell Adhesion
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