ACAT1

Description		acetyl-CoA acetyltransferase 1
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum Extracellular Exosome
	Molecular Function	Acetyl-CoA C-acetyltransferase Activity C-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Enzyme Binding Potassium Ion Binding Cholesterol O-acyltransferase Activity Identical Protein Binding Metal Ion Binding Coenzyme A Binding
	Biological Process	Liver Development Acetyl-CoA Biosynthetic Process L-isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Response To Hormone Coenzyme A Metabolic Process Coenzyme A Biosynthetic Process Response To Starvation Acetyl-CoA Catabolic Process Ketone Body Catabolic Process Adipose Tissue Development Metanephric Proximal Convoluted Tubule Development Ketone Body Metabolic Process Propionyl-CoA Biosynthetic Process
Pathways		Branched-chain amino acid catabolism Utilization of Ketone Bodies Synthesis of Ketone Bodies Mitochondrial protein degradation Maturation of TCA enzymes and regulation of TCA cycle Beta-ketothiolase deficiency
Drugs		Sulfasalazine Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS		Nonunion in individuals with fractures ( 30680360) Refractive error ( 32231278)
Novel Interacting Genes		5 novel interacting genes: AGXT CXCR4 PDP1 PEX7 PTPRF
Interacting Genes		5 interacting genes: AGXT CXCR4 PDP1 PEX7 PTPRF
Entrez ID		38
HPRD ID		01946
Ensembl ID		ENSG00000075239
Uniprot IDs		A0A140VJX1 A0A5F9ZHJ0 A0A5F9ZHL1 A0A5F9ZI66 P24752
PDB IDs		2F2S 2IB7 2IB8 2IB9 2IBU 2IBW 2IBY
Enriched GO Terms of Interacting Partners?		Peroxisomal Matrix L-serine-pyruvate Transaminase Activity Peroxisome Matrix Targeting Signal-2 Binding Chondroitin Sulfate Proteoglycan Binding Protein Dephosphorylation C-X-C Motif Chemokine 12 Receptor Activity Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex Glycine Biosynthetic Process, By Transamination Of Glyoxylate Peroxisome Oxalic Acid Secretion Dephosphorylation Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Phosphoprotein Phosphatase Activity Glycine Biosynthetic Process Glyoxylate Catabolic Process L-alanine Catabolic Process Alanine-glyoxylate Transaminase Activity L-alanine Metabolic Process L-cysteine Catabolic Process Cell Migration Negative Regulation Of Receptor Binding Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway [pyruvate Dehydrogenase (acetyl-transferring)]-phosphatase Activity Carboxylic Acid Catabolic Process CXCL12-activated CXCR4 Signaling Pathway Cell Motility Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Myosin Light Chain Binding C-X-C Chemokine Receptor CXCR4 Signaling Pathway Oxalate Transport Glyoxylate Metabolic Process Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway C-X-C Chemokine Receptor Activity Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Peptidyl-threonine Dephosphorylation Protein Targeting To Peroxisome Regulation Of Acyl-CoA Biosynthetic Process Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Serine Family Amino Acid Catabolic Process Ether Lipid Biosynthetic Process Glycine Metabolic Process Aldehyde Catabolic Process Amino Acid Binding L-serine Metabolic Process Protein Import Into Peroxisome Matrix Myelin Maintenance Cation Binding Transmembrane Receptor Protein Tyrosine Phosphatase Activity Dendritic Cell Chemotaxis
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