KCNN2

Description		potassium calcium-activated channel subfamily N member 2
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Z Disc Neuronal Cell Body Dendritic Spine
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding Calmodulin Binding Calcium-activated Potassium Channel Activity Small Conductance Calcium-activated Potassium Channel Activity Protein Domain Specific Binding Protein Homodimerization Activity Alpha-actinin Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport
Pathways		Ca2+ activated K+ channels Acetylcholine inhibits contraction of outer hair cells
Drugs		Procaine Ritodrine Nitrendipine Miconazole Colforsin Trimebutine Rimtuzalcap
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Atrial fibrillation ( 28416818 29892015 30061737 33990960) Coronary arterial lesions in patients with Kawasaki disease ( 23677057) Diastolic blood pressure ( 27841878) Generalized epilepsy ( 30531953) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) JT interval (sulfonylurea treatment interaction) ( 27958378) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Systolic blood pressure ( 27841878)
Novel Interacting Genes		5 novel interacting genes: ACTN2 CALM1 DCP2 SRPK1 SRPK2
Interacting Genes		5 interacting genes: ACTN2 CALM1 DCP2 SRPK1 SRPK2
Entrez ID		3781
HPRD ID		09323
Ensembl ID		ENSG00000080709
Uniprot IDs		A0A3F2YNY5 Q9H2S1
PDB IDs		5V02 5WBX 5WC5 6ALE
Enriched GO Terms of Interacting Partners?		Titin Binding Regulation Of MRNA Metabolic Process Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Sarcomere Positive Regulation Of Viral Process Regulation Of Transmembrane Transporter Activity Actin Filament Uncapping Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Viral Genome Replication Negative Regulation Of Viral Process RNA Exonuclease Activity, Producing 5'-phosphomonoesters Negative Regulation Of Monoatomic Ion Transport Regulation Of Viral Life Cycle MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Transmembrane Transporter Binding Titin Z Domain Binding Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of MRNA Processing Regulation Of Viral Process Phospholipase C-activating Angiotensin-activated Signaling Pathway Microspike Assembly Regulation Of RNA Splicing Nuclear Speck Organization 5'-3' RNA Exonuclease Activity Cell Junction FATZ Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Magnesium Ion Binding Protein-RNA Complex Assembly Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity LIM Domain Binding Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Autophagosome Membrane Docking Positive Regulation Of Endocytic Recycling Regulation Of Monoatomic Cation Transmembrane Transport Negative Regulation Of Voltage-gated Calcium Channel Activity R-loop Processing Regulation Of Monoatomic Ion Transmembrane Transport Postsynaptic Actin Cytoskeleton
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