ITPKB

Description		inositol-trisphosphate 3-kinase B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Cytoskeleton Membrane
	Molecular Function	Nucleotide Binding Inositol Hexakisphosphate Kinase Activity Protein Binding Calmodulin Binding ATP Binding Inositol-1,4,5-trisphosphate 3-kinase Activity Kinase Activity Transferase Activity
	Biological Process	MAPK Cascade Myeloid Cell Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway T Cell Differentiation Inositol Trisphosphate Metabolic Process Inositol Phosphate Biosynthetic Process Negative Regulation Of Neutrophil Apoptotic Process Common Myeloid Progenitor Cell Proliferation Positive Thymic T Cell Selection Thymic T Cell Selection Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Alpha-beta T Cell Differentiation Phosphatidylinositol Phosphate Biosynthetic Process Cellular Response To Calcium Ion
Pathways		Synthesis of IP3 and IP4 in the cytosol
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Dentures ( 31235808) Eosinophil percentage of white cells ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Parkinson's disease ( 28892059 32201043 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Subcutaneous adipose tissue ( 22589738)
Novel Interacting Genes		14 novel interacting genes: AKT1 CALM1 CEP70 CTDSP1 GOLGA2 IFT88 KRT34 PPP3CA PRKACA PRKCA PSME3 SCAI TRIM54 UBQLN2
Interacting Genes		14 interacting genes: AKT1 CALM1 CEP70 CTDSP1 GOLGA2 IFT88 KRT34 PPP3CA PRKACA PRKCA PSME3 SCAI TRIM54 UBQLN2
Entrez ID		3707
HPRD ID		00942
Ensembl ID		ENSG00000143772
Uniprot IDs		B2R9J0 P27987
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Angiotensin-activated Signaling Pathway Vascular Endothelial Cell Response To Fluid Shear Stress Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cilium Regulation Of Vesicle-mediated Transport Proteasomal Protein Catabolic Process Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Muscle System Process Regulation Of Calcium-mediated Signaling Response To Laminar Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Cholesterol Biosynthetic Process Ciliary Basal Body Proteolysis Involved In Protein Catabolic Process Regulation Of Metal Ion Transport Protein Catabolic Process Regulation Of Cell Cycle Negative Regulation Of Transmembrane Transport Renal System Process Renal Sodium Ion Absorption Renal Sodium Ion Transport Regulation Of Protein Catabolic Process Response To Calcium Ion Regulation Of Autophagy Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Calcium Channel Complex Regulation Of Calcium Ion Transmembrane Transport Calcineurin-mediated Signaling Regulation Of Cellular Component Organization Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Cholesterol Metabolic Process Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cholesterol Biosynthetic Process Cellular Response To Fluid Shear Stress Negative Regulation Of Transport Calcium-mediated Signaling Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cilium Assembly Regulation Of Nervous System Development Positive Regulation Of Steroid Biosynthetic Process Protein Kinase Binding Regulation Of Cell Cycle G1/S Phase Transition
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