IL5RA

Description		interleukin 5 receptor subunit alpha
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-5 Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Inflammatory Response To Antigenic Stimulus Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Eosinophil Differentiation Regulation Of Interleukin-5 Production Interleukin-5-mediated Signaling Pathway Positive Regulation Of Leukocyte Proliferation
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs		Dimethyl sulfoxide Benralizumab
Diseases
GWAS		Asthma (childhood onset) ( 22560479) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Blood protein levels ( 30072576) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Oleic acid (18:1n-9) levels ( 23362303) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 27863252)
Novel Interacting Genes		7 novel interacting genes: CSF2RB EGFR IL5 JAK1 JAK2 SDCBP UNC119
Interacting Genes		7 interacting genes: CSF2RB EGFR IL5 JAK1 JAK2 SDCBP UNC119
Entrez ID		3568
HPRD ID		00998
Ensembl ID		ENSG00000091181
Uniprot IDs		Q01344 Q8NHV7
PDB IDs		1OBX 1OBZ 3QT2 3VA2 6H41 8TLD
Enriched GO Terms of Interacting Partners?		Interleukin-5-mediated Signaling Pathway Interleukin-5 Receptor Binding Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Interleukin-3-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Interleukin-3 Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Phosphate Metabolic Process Growth Hormone Receptor Binding Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Focal Adhesion Regulation Of Phosphorylation Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein Tyrosine Kinase Activity Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Leukocyte Proliferation Regulation Of Phosphorus Metabolic Process Growth Hormone Receptor Signaling Pathway Signal Transduction Membrane Raft Negative Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Protein Phosphorylation Response To Antibiotic Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Leukocyte Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Multivesicular Body, Internal Vesicle Lumen Regulation Of Receptor Signaling Pathway Via JAK-STAT Interferon-mediated Signaling Pathway Cellular Response To Virus Histone H3Y41 Kinase Activity Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway Symbiont-induced Defense-related Programmed Cell Death Interleukin-35-mediated Signaling Pathway Negative Regulation Of Endocytosis Interleukin-5 Receptor Complex Cellular Response To Cytokine Stimulus
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