POLN

Description		DNA polymerase nu
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Nucleic Acid Binding DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity Cyclin Binding DNA Polymerase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Repair Double-strand Break Repair DNA Damage Response Translesion Synthesis Interstrand Cross-link Repair
Pathways		Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Alzheimer's disease ( 22159054) Diastolic blood pressure ( 30224653) Diffusing capacity of carbon monoxide ( 30694715) Height ( 31562340)
Novel Interacting Genes		2 novel interacting genes: ATR POLDIP2
Interacting Genes		2 interacting genes: ATR POLDIP2
Entrez ID		353497
HPRD ID		17876
Ensembl ID		ENSG00000130997
Uniprot IDs		Q7Z5Q5
PDB IDs		4XVI 4XVK 4XVL 4XVM
Enriched GO Terms of Interacting Partners?		Establishment Of Protein-containing Complex Localization To Telomere ATR-ATRIP Complex Establishment Of RNA Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Histone H2AXS139 Kinase Activity Positive Regulation Of Cellular Component Biogenesis Regulation Of Mitotic Cell Cycle MutSalpha Complex Binding DNA Repair MutLalpha Complex Binding Error-free Translesion Synthesis Smooth Muscle Cell Proliferation Vascular Associated Smooth Muscle Cell Proliferation Protein Localization To Chromosome, Telomeric Region Membrane Disassembly Regulation Of Cellular Response To Heat DNA Metabolic Process Nuclear Membrane Disassembly Regulation Of Cell Cycle Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Strand Resection Involved In Replication Fork Processing Replicative Senescence Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis DNA Damage Response Negative Regulation Of DNA Replication Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Nuclear Envelope Organization Protein Localization To Site Of Double-strand Break Translesion Synthesis Cellular Response To Gamma Radiation Response To Arsenic-containing Substance Positive Regulation Of Focal Adhesion Assembly Replication Fork Processing Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cellular Component Organization Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Site Of DNA Damage Positive Regulation Of DNA Biosynthetic Process Interstrand Cross-link Repair Regulation Of Cell Cycle Positive Regulation Of Signal Transduction By P53 Class Mediator Muscle Cell Proliferation DNA Synthesis Involved In DNA Repair Postreplication Repair Positive Regulation Of Cytokinesis Negative Regulation Of Macroautophagy Mitotic Spindle Assembly Mitochondrial Nucleoid
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