NUP43

Description		nucleoporin 43
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Chromosome Cytosol Nuclear Speck Nuclear Pore Outer Ring
	Molecular Function	Protein Binding
	Biological Process	Nucleocytoplasmic Transport Chromosome Segregation Protein Transport MRNA Transport Cell Division
Pathways		ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Novel Interacting Genes		4 novel interacting genes: CRYAA DSCAM NUP37 SYNE1
Interacting Genes		4 interacting genes: CRYAA DSCAM NUP37 SYNE1
Entrez ID		348995
HPRD ID		12174
Ensembl ID		ENSG00000120253
Uniprot IDs		Q8NFH3 Q8TEA6
PDB IDs		4I79 5A9Q 7PEQ 7R5J 7R5K
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Growth Positive Regulation Of Growth Post-embryonic Retina Morphogenesis In Camera-type Eye Positive Regulation Of Axon Extension Involved In Axon Guidance Netrin Receptor Binding Nuclear Envelope Nuclear Matrix Organization Cytoskeleton-nuclear Membrane Anchor Activity Nuclear Matrix Anchoring At Nuclear Membrane Lens Fiber Cell Morphogenesis Regulation Of Cell Growth Tubulin Complex Assembly Response To UV-A Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Netrin-activated Signaling Pathway Regulation Of Axon Extension Involved In Axon Guidance Dendrite Self-avoidance Camera-type Eye Photoreceptor Cell Differentiation Dendritic Spine Development Meiotic Nuclear Membrane Microtubule Tethering Complex Lamin Binding Nuclear Pore Outer Ring Eye Photoreceptor Cell Differentiation
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