IGFBP2

Description		insulin like growth factor binding protein 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Phosphatase Inhibitor Activity Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Signaling Receptor Inhibitor Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Receptor Ligand Inhibitor Activity
	Biological Process	Osteoblast Differentiation Female Pregnancy Response To Nutrient Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Estradiol Response To Retinoic Acid Cellular Response To Hormone Stimulus Positive Regulation Of Activated T Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Estrogen Negative Regulation Of Osteoblast Differentiation Response To Steroid Hormone Response To Glucocorticoid Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Glomerular filtration rate (creatinine) ( 28452372) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) Mitral valve prolapse ( 26301497) Thyroid stimulating hormone levels ( 25743335) Type 2 diabetes ( 26818947)
Novel Interacting Genes		9 novel interacting genes: BMPR2 CASP10 GSDMB IGF1 IGF2 INO80B KLK2 RPS6KA1 TF
Interacting Genes		9 interacting genes: BMPR2 CASP10 GSDMB IGF1 IGF2 INO80B KLK2 RPS6KA1 TF
Entrez ID		3485
HPRD ID		00898
Ensembl ID		ENSG00000115457
Uniprot IDs		C9JMY1 P18065
PDB IDs		2H7T
Enriched GO Terms of Interacting Partners?		Lung Vasculature Development Positive Regulation Of Growth Exocrine Pancreas Development Osteoblast Differentiation Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Developmental Growth Insulin Receptor Binding Epithelial Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Cellular Component Organization Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Growth Regulation Of Glycogen Metabolic Process Blood Vessel Remodeling Regulation Of Activated T Cell Proliferation Lung Alveolus Development Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Organ Growth Vasculature Development Extracellular Space Proteoglycan Biosynthetic Process Regulation Of Cellular Component Organization Regulation Of Developmental Growth Basal Plasma Membrane Platelet Alpha Granule Lumen Negative Regulation Of Oocyte Development Clathrin-coated Pit Negative Regulation Of Muscle Cell Differentiation Striated Muscle Cell Differentiation Positive Regulation Of Osteoblast Differentiation Insulin Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Tissue Remodeling Proteoglycan Metabolic Process Positive Regulation Of Cell Activation Regulation Of Cell Growth Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Positive Regulation Of Trophectodermal Cell Proliferation Regulation Of Organ Growth Cytotoxic T Cell Pyroptotic Cell Death Positive Regulation Of RNA Metabolic Process Regulation Of Glucose Metabolic Process Secretory Granule
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