IFNA2

Description		interferon alpha 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Type I Interferon Receptor Binding Protein Binding
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response B Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Apoptotic Process Defense Response Inflammatory Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Gene Expression Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-5 Production Response To Exogenous DsRNA Negative Regulation Of T Cell Differentiation Negative Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Defense Response To Virus Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Negative Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling TRAF6 mediated IRF7 activation SARS-CoV-2 activates/modulates innate and adaptive immune responses Factors involved in megakaryocyte development and platelet production Evasion by RSV of host interferon responses
Drugs		Sifalimumab
Diseases
GWAS		Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494)
Novel Interacting Genes		3 novel interacting genes: IFNAR1 IFNAR2 TIMMDC1
Interacting Genes		3 interacting genes: IFNAR1 IFNAR2 TIMMDC1
Entrez ID		3440
HPRD ID		00950
Ensembl ID		ENSG00000188379
Uniprot IDs		P01563
PDB IDs		1ITF 1RH2 2HYM 2KZ1 2LAG 2LMS 3S9D 3SE3 4YPG 4Z5R
Enriched GO Terms of Interacting Partners?		Type I Interferon Receptor Activity Type I Interferon Binding JAK Pathway Signal Transduction Adaptor Activity Response To Interferon-alpha Cellular Response To Interferon-beta Response To Interferon-beta Cytokine Binding Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Virus Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Localization To Nucleus Regulation Of Protein Localization To Nucleus Interferon Receptor Activity Receptor Complex Response To Virus Cellular Response To Interferon-alpha Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Localization Positive Regulation Of Cellular Respiration Response To Cytokine Response To Peptide Mitochondrial Respiratory Chain Complex I Assembly NADH Dehydrogenase Complex Assembly Regulation Of Cellular Respiration Regulation Of Protein Localization Response To Other Organism Mitochondrial Respiratory Chain Complex Assembly Response To External Biotic Stimulus
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