IDUA

Description		alpha-L-iduronidase
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GO Annotations	Cellular Component	Lysosome Lysosomal Lumen Extracellular Exosome
	Molecular Function	L-iduronidase Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Signaling Receptor Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds
	Biological Process	Carbohydrate Metabolic Process Disaccharide Metabolic Process Glycosaminoglycan Catabolic Process Heparan Sulfate Proteoglycan Catabolic Process Dermatan Sulfate Proteoglycan Catabolic Process Heparin Proteoglycan Catabolic Process
Pathways		HS-GAG degradation CS/DS degradation MPS I - Hurler syndrome (HS-GAG degradation) MPS I - Hurler syndrome (CS/DS degradation)
Drugs
Diseases		Mucopolysaccharidosis type I (MPS1); Hurler-Scheie syndrome (MPS1HS); Hurler syndrome (MPS1H); Scheie syndrome (MPS1S)
GWAS		A body shape index ( 34021172) Blood protein levels ( 30072576) Heel bone mineral density ( 30598549) Limited cutaneous systemic scleroderma ( 29293537) Lumbar spine bone mineral density ( 22504420) Mean reticulocyte volume ( 32888494) Polymyositis ( 26362759) Primary biliary cholangitis ( 26394269)
Novel Interacting Genes		2 novel interacting genes: FGFR3 MPP3
Interacting Genes		2 interacting genes: FGFR3 MPP3
Entrez ID		3425
HPRD ID		02016
Ensembl ID		ENSG00000127415
Uniprot IDs		P35475
PDB IDs		3W81 3W82 4KGJ 4KGL 4KH2 4MJ2 4MJ4 4OBR 4OBS 6I6R 6I6X
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Positive Regulation Of Phospholipase Activity Bone Maturation Fibroblast Growth Factor Receptor Activity Endochondral Bone Growth Positive Regulation Of Lipase Activity Chondrocyte Proliferation Bone Growth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Fibroblast Growth Factor Binding Regulation Of Tyrosine Phosphorylation Of STAT Protein Endochondral Ossification Bone Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Chondrocyte Differentiation Transmembrane Receptor Protein Tyrosine Kinase Activity Organ Growth Bone Mineralization Fibroblast Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT
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