HYAL1

Description		hyaluronidase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Cytoplasmic Vesicle Hyaluranon Cable Lysosomal Lumen Extracellular Exosome
	Molecular Function	Virus Receptor Activity Hyalurononglucosaminidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Chondroitin Hydrolase Activity
	Biological Process	Response To Reactive Oxygen Species Carbohydrate Metabolic Process Glycosaminoglycan Catabolic Process Inflammatory Response Response To Virus Chondroitin Sulfate Proteoglycan Catabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Cellular Response To Platelet-derived Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Response To Antibiotic Cartilage Development Embryonic Skeletal Joint Morphogenesis Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To PH Cellular Response To UV-B Positive Regulation Of Hyaluranon Cable Assembly
Pathways		CS/DS degradation Hyaluronan degradation MPS IX - Natowicz syndrome (Hyaluronan metabolism) MPS IX - Natowicz syndrome (CS/DS degradation)
Drugs
Diseases		Mucopolysaccharidosis type IX (MPS9); Hyaluronidase deficiency
GWAS		Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Sleep duration (short sleep) ( 30846698)
Novel Interacting Genes		2 novel interacting genes: COL2A1 PRKAR2A
Interacting Genes		2 interacting genes: COL2A1 PRKAR2A
Entrez ID		3373
HPRD ID		06146
Ensembl ID		ENSG00000114378
Uniprot IDs		A0A024R2X3 A0A0S2Z3Q0 B3KUI5 Q12794
PDB IDs		2PE4
Enriched GO Terms of Interacting Partners?		Fibrillar Collagen Trimer Collagen Type XI Trimer Otic Vesicle Development Collagen Type II Trimer Notochord Development Platelet-derived Growth Factor Binding MHC Class II Protein Binding Limb Bud Formation Anterior Head Development Nucleotide-activated Protein Kinase Complex CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Embryonic Skeletal Joint Morphogenesis Proteoglycan Binding Protein Kinase A Catalytic Subunit Binding Cartilage Condensation Cartilage Development Involved In Endochondral Bone Morphogenesis CAMP Binding Cell Aggregation Head Development Negative Regulation Of CAMP/PKA Signal Transduction Endochondral Ossification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Extracellular Matrix Structural Constituent Conferring Tensile Strength Cellular Response To BMP Stimulus Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Plasma Membrane Raft Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Ciliary Base Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Signal Transduction Heart Morphogenesis Inner Ear Development Collagen Fibril Organization Chondrocyte Differentiation Inner Ear Morphogenesis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Bone Development Collagen Trimer Roof Of Mouth Development Embryonic Skeletal System Morphogenesis Proteoglycan Metabolic Process Basement Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Limb Morphogenesis Cartilage Development Skeletal System Morphogenesis Extracellular Matrix Structural Constituent
Tagcloud ?