HTR1A

Description		5-hydroxytryptamine receptor 1A
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GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Cell Projection Synapse
	Molecular Function	Gi/o-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Receptor-receptor Interaction Serotonin Receptor Activity
	Biological Process	Behavioral Fear Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Regulation Of Serotonin Secretion Regulation Of Vasoconstriction Exploration Behavior Regulation Of Dopamine Metabolic Process Serotonin Metabolic Process Regulation Of Hormone Secretion Regulation Of Behavior
Pathways		Serotonin receptors
Drugs		Eletriptan Ziprasidone Methysergide Cabergoline Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Loxapine Pramipexole Methylphenidate Imipramine Chlorpromazine Buspirone Haloperidol Nortriptyline Amoxapine Propranolol Fenfluramine Lisuride Trazodone Sumatriptan Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Alprenolol Ondansetron Oxymetazoline Naratriptan Pindolol Dopamine Ergoloid mesylate Doxepin Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Paliperidone Penbutolol Yohimbine Acepromazine Alverine Molindone Pipotiazine Lysergic acid diethylamide Dapoxetine Bifeprunox Flibanserin Iloperidone Lofexidine Lesopitron Rotigotine MN-305 LI-301 Naluzotan Cariprazine Mianserin Pizotifen Asenapine Xaliproden Dotarizine Sarizotan Repinotan Robalzotan Vilazodone Bopindolol Cinitapride Lurasidone Perospirone Cannabidiol Vortioxetine Brexpiprazole Dosulepin Pirlindole Tianeptine Setiptiline Dihydroergocornine Tetrahydrocannabivarin Pardoprunox Gilteritinib Lecozotan Lecozotan Tiapride Dihydroergocristine Medical Cannabis 5-methoxy-N,N-dimethyltryptamine Nabiximols Aripiprazole lauroxil SEP-363856 Serdexmethylphenidate
Diseases
GWAS		Adult body size ( 32376654) Alcohol and nicotine co-dependence ( 23216389) Body mass index ( 20935630) Bronchopulmonary dysplasia ( 23897914) Daytime nap ( 33568662) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Novel Interacting Genes		8 novel interacting genes: FGFR1 GABBR2 GNAI3 GPR26 HTR1B HTR1D S1PR1 S1PR3
Interacting Genes		8 interacting genes: FGFR1 GABBR2 GNAI3 GPR26 HTR1B HTR1D S1PR1 S1PR3
Entrez ID		3350
HPRD ID		00190
Ensembl ID		ENSG00000178394
Uniprot IDs		A8K5W4 P08908 Q5ZGX3
PDB IDs		7E2X 7E2Y 7E2Z 8FY8 8FYE 8FYL 8FYT 8FYX 8JSP 8JT6 8PJK 8PKM 8W8B
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Gi/o-coupled Serotonin Receptor Activity Sphingosine-1-phosphate Receptor Activity Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Signal Transduction G Protein-coupled Serotonin Receptor Activity Serotonin Receptor Activity Sphingosine-1-phosphate Receptor Signaling Pathway Sphingolipid Mediated Signaling Pathway Plasma Membrane Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Cell-cell Signaling Vasoconstriction Signaling Cell Communication G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Cardiac Muscle Tissue Growth Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Parathyroid Hormone Secretion Trans-synaptic Signaling Synaptic Signaling G Protein-coupled Receptor Binding Regulation Of Behavior Membrane Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Establishment Of Endothelial Barrier Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Regulation Of Lateral Mesodermal Cell Fate Specification Serotonergic Synapse Negative Regulation Of Serotonin Secretion G Protein-coupled GABA Receptor Complex G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Heterodimeric Complex Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Ventricular Zone Neuroblast Division Regulation Of Mitotic Cell Cycle DNA Replication Orbitofrontal Cortex Development GABA Receptor Complex Sphingolipid Binding Growth Involved In Heart Morphogenesis Positive Regulation Of Chemotaxis
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