APLP2

Description		amyloid beta precursor like protein 2
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GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Lumen Plasma Membrane Membrane Platelet Alpha Granule Platelet Alpha Granule Membrane Extracellular Exosome
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Peptidase Inhibitor Activity Identical Protein Binding Metal Ion Binding Transition Metal Ion Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Axonogenesis Central Nervous System Development
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576)
Novel Interacting Genes		26 novel interacting genes: AKT1 APBB1 APBB2 APBB3 BRCA1 CDK1 DAB1 DAB2 DEDD ETS1 GNAO1 HGS HLA-A JUN JUNB KAT5 KCNJ1 MAPK8 PIK3CA PRKCA PRNP RPL26 SLC13A1 UBC VKORC1 ZNF512B
Interacting Genes		26 interacting genes: AKT1 APBB1 APBB2 APBB3 BRCA1 CDK1 DAB1 DAB2 DEDD ETS1 GNAO1 HGS HLA-A JUN JUNB KAT5 KCNJ1 MAPK8 PIK3CA PRKCA PRNP RPL26 SLC13A1 UBC VKORC1 ZNF512B
Entrez ID		334
HPRD ID		00103
Ensembl ID		ENSG00000084234
Uniprot IDs		A0A140VJE9 B4E3I5 Q06481
PDB IDs		5JBT 5TPT 8RQ6
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Gene Expression Regulation Of Protein Localization Regulation Of Multicellular Organismal Process Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Leading Edge Cell Differentiation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Localization Apoptotic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Peptidyl-threonine Phosphorylation Programmed Cell Death Cell Death Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Macromolecule Metabolic Process Low-density Lipoprotein Particle Receptor Binding Protein Localization To Site Of Double-strand Break Amyloid-beta Binding Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Establishment Of Protein Localization Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Response To Lipid Response To Steroid Hormone Regulation Of Cell Adhesion Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Intracellular Signaling Cassette Integrated Stress Response Signaling Transcription Factor AP-1 Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Positive Regulation Of Transcription By RNA Polymerase II
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