HRG

Description		histidine rich glycoprotein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding Immunoglobulin Binding Heme Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding
	Biological Process	Angiogenesis Positive Regulation Of Immune Response To Tumor Cell Chemotaxis Negative Regulation Of Cell Adhesion Blood Coagulation Hemostasis Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Regulation Of Platelet Activation Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Angiogenesis Platelet Activation Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Cell Adhesion Mediated By Integrin Fibrinolysis Positive Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Fungus Cytolysis By Host Of Symbiont Cells Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Fibrinolysis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Endothelial Cell Chemotaxis
Pathways		Platelet degranulation Dissolution of Fibrin Clot
Drugs		Zinc chloride Zinc sulfate, unspecified form
Diseases		Inherited thrombophilia
GWAS		Activated partial thromboplastin time ( 20303064 22703881) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neurological blood protein biomarker levels ( 31320639) Refractive error ( 32231278)
Novel Interacting Genes		15 novel interacting genes: C1QA C1QB CHRD CYSRT1 FCGR1A FGA FN1 PLG PLSCR1 RABAC1 RCHY1 RGS20 SPRY1 THBS1 TNFRSF1A
Interacting Genes		15 interacting genes: C1QA C1QB CHRD CYSRT1 FCGR1A FGA FN1 PLG PLSCR1 RABAC1 RCHY1 RGS20 SPRY1 THBS1 TNFRSF1A
Entrez ID		3273
HPRD ID		00812
Ensembl ID		ENSG00000113905
Uniprot IDs		P04196
PDB IDs
Enriched GO Terms of Interacting Partners?		Blood Coagulation, Fibrin Clot Formation Fibrinogen Complex IgG Binding Platelet Alpha Granule Lumen Protein Activation Cascade Extracellular Matrix Complement Component C1q Complex Blood Microparticle Biological Process Involved In Interaction With Symbiont Defense Response IgM Binding Complement Component C1 Complex Cell Surface Phosphatidylserine Binding Acute Inflammatory Response Synapse Pruning Regulation Of Hemostasis Regulation Of Blood Coagulation Regulation Of Cell-substrate Adhesion Negative Regulation Of Fibrinolysis Proteoglycan Binding Inflammatory Response Regulation Of Fibrinolysis Protease Binding Symbiont Cell Surface Platelet Alpha Granule Fibrinolysis Extracellular Matrix Structural Constituent Protein Maturation Extracellular Region Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus External Side Of Plasma Membrane Negative Regulation Of Protein Maturation Response To Other Organism Regulation Of Wound Healing Positive Regulation Of Blood Coagulation Negative Regulation Of Multicellular Organismal Process Phagocytosis, Engulfment Positive Regulation Of Coagulation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Response To Stress Complement Activation, Classical Pathway Regulation Of Cell Adhesion Regulation Of Response To Wounding Response To External Biotic Stimulus Acute-phase Response Membrane Invagination High-affinity IgG Receptor Activity Regulation Of Cell Communication
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