HPRT1

Description		hypoxanthine phosphoribosyltransferase 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Identical Protein Binding Metal Ion Binding Guanine Phosphoribosyltransferase Activity
	Biological Process	T Cell Mediated Cytotoxicity Response To Amphetamine Purine Nucleotide Biosynthetic Process Purine Ribonucleoside Salvage Guanine Salvage Grooming Behavior Locomotory Behavior Striatum Development Cerebral Cortex Neuron Differentiation Central Nervous System Neuron Development GMP Salvage IMP Salvage Dopamine Metabolic Process Hypoxanthine Salvage AMP Salvage Positive Regulation Of Dopamine Metabolic Process GMP Catabolic Process IMP Metabolic Process Adenine Metabolic Process Hypoxanthine Metabolic Process Lymphocyte Proliferation Dendrite Morphogenesis Protein Homotetramerization Dopaminergic Neuron Differentiation
Pathways		Purine salvage Defective HPRT1 disrupts guanine and hypoxanthine salvage Azathioprine ADME
Drugs		Mercaptopurine 5-O-phosphono-alpha-D-ribofuranosyl diphosphate 5-monophosphate-9-beta-D-ribofuranosyl xanthine 3H-pyrazolo[4,3-d]pyrimidin-7-ol 9-Deazaguanine
Diseases		Lesch-Nyhan syndrome; Hypoxanthine-guanine phosophoribosyltransferase deficiency
GWAS		Estimated glomerular filtration rate ( 31015462)
Novel Interacting Genes		12 novel interacting genes: CEBPA EEF2KMT EFCAB3 FANCA GNMT ISCU NTAQ1 PCNT PRTFDC1 SDCBP SPG21 SREK1IP1
Interacting Genes		12 interacting genes: CEBPA EEF2KMT EFCAB3 FANCA GNMT ISCU NTAQ1 PCNT PRTFDC1 SDCBP SPG21 SREK1IP1
Entrez ID		3251
HPRD ID		02388
Ensembl ID		ENSG00000165704
Uniprot IDs		A0A140VJL3 P00492
PDB IDs		1BZY 1D6N 1HMP 1Z7G 2VFA 3GEP 3GGC 3GGJ 4IJQ 4KN6 4RAB 4RAC 4RAD 4RAN 4RAO 4RAQ 5BRN 5BSK 5HIA 5W8V 6BNJ 7SAN 8TPY
Enriched GO Terms of Interacting Partners?		Purine Nucleoside Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex Negative Regulation Of Iron Ion Import Across Plasma Membrane Iron-sulfur Cluster Chaperone Activity Negative Regulation Of Iron Ion Transmembrane Transport Sarcosine Metabolic Process Nucleoside Metabolic Process Glycine N-methyltransferase Activity S-adenosylhomocysteine Metabolic Process Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Hypoxanthine Phosphoribosyltransferase Activity Guanine Salvage
Tagcloud ?