HPD

Description		4-hydroxyphenylpyruvate dioxygenase
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Extracellular Exosome
	Molecular Function	4-hydroxyphenylpyruvate Dioxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Protein Homodimerization Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	L-phenylalanine Catabolic Process L-tyrosine Catabolic Process Aromatic Amino Acid Metabolic Process
Pathways		Tyrosine catabolism
Drugs		Nitisinone DAS869
Diseases		Tyrosinemia; Tyrosinemia, type I; Tyrosinemia, type II; Tyrosinemia, type III; Hawkinsinuria
GWAS		HDL cholesterol levels ( 32203549) Obesity-related traits ( 23251661) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolites ( 21572414 26352407)
Novel Interacting Genes		6 novel interacting genes: CDK6 CDKN1A HIVEP1 IKBKG RIDA STK33
Interacting Genes		6 interacting genes: CDK6 CDKN1A HIVEP1 IKBKG RIDA STK33
Entrez ID		3242
HPRD ID		02041
Ensembl ID		ENSG00000158104
Uniprot IDs		P32754
PDB IDs		3ISQ 5EC3 8IM2 8IM3
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition Positive Regulation Of Fibroblast Proliferation Cyclin Binding DNA Damage Response G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Cyclin D2-CDK6 Complex Cyclin-dependent Protein Kinase Holoenzyme Complex Mitotic DNA Integrity Checkpoint Signaling Mitotic DNA Damage Checkpoint Signaling 2-iminopropanoate Deaminase Activity 2-iminobutanoate/2-iminopropanoate Deaminase L-threonine Catabolic Process To Glycine RNA Endonuclease Activity Producing 3'-phosphomonoesters, Hydrolytic Mechanism 2-iminobutanoate Deaminase Activity Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Cyclin D3-CDK6 Complex Regulation Of Fibroblast Proliferation Cyclin D1-CDK6 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle FBXO Family Protein Binding PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration DNA Damage Checkpoint Signaling L-threonine Catabolic Process Cellular Response To Stress Positive Regulation Of Macromolecule Metabolic Process Linear Polyubiquitin Binding Threonine Metabolic Process Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Cell Cycle Phase Transition Regulation Of Cell Cycle Process Cellular Response To Cell-matrix Adhesion Positive Regulation Of Metabolic Process Gliogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Monocyte Differentiation Cell Dedifferentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Oncogene-induced Cell Senescence Stress-induced Premature Senescence Negative Regulation Of Mitotic Cell Cycle IkappaB Kinase Complex Manchette Assembly Negative Regulation Of Cell Cycle Phase Transition Nucleus Deaminase Activity
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