HNMT

Description		histamine N-methyltransferase
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Extracellular Exosome
	Molecular Function	Methyltransferase Activity N-methyltransferase Activity Transferase Activity Histamine N-methyltransferase Activity
	Biological Process	Histamine Metabolic Process Histamine Catabolic Process L-histidine Catabolic Process Respiratory Gaseous Exchange By Respiratory System Methylation
Pathways		Metabolism of ingested SeMet, Sec, MeSec into H2Se Histidine catabolism
Drugs		Amodiaquine S-adenosyl-L-homocysteine Metoprine SKF-91488 Harmaline
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Metabolite levels ( 23823483)
Novel Interacting Genes		6 novel interacting genes: CAMK2D CFTR CLK1 POT1 TERF1 TINF2
Interacting Genes		6 interacting genes: CAMK2D CFTR CLK1 POT1 TERF1 TINF2
Entrez ID		3176
HPRD ID		05575
Ensembl ID		ENSG00000150540
Uniprot IDs		B4DWC1 P50135
PDB IDs		1JQD 1JQE 2AOT 2AOU 2AOV 2AOW 2AOX
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomeric D-loop Disassembly Telomere Maintenance Positive Regulation Of Chromosome Organization G-rich Strand Telomeric DNA Binding Regulation Of Telomere Maintenance Telomeric Loop Disassembly Telomere Organization Negative Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process Chromosome Organization Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding DNA Biosynthetic Process Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Positive Regulation Of Anion Channel Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Telomeric Loop Disassembly Perinucleolar Chromocenter Positive Regulation Of Monoatomic Anion Transport
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