HLA-DQA2

Description		major histocompatibility complex, class II, DQ alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling
Drugs
Diseases
GWAS		A body shape index ( 34021172) Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Age at first birth ( 34211149) Alopecia areata ( 20596022) Asthma ( 21804548 31959851 31619474) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 27539887) Body mass index ( 25673413) Chronic hepatitis B infection ( 24940741) Coffee consumption (cups per day) ( 31837886) Crohn's disease ( 23266558 26891255 21102463) Frailty index ( 34431594) Giant cell arteritis ( 28041642) Glycated hemoglobin levels ( 31213470) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Height ( 31562340) Hepatitis C (spontaneous viral clearance) ( 30593799) Hypothyroidism ( 22493691) IgA levels ( 28628107) IgE levels ( 22075330 23146381) IgG glycosylation ( 23382691) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Knee osteoarthritis ( 20305777) Low density lipoprotein cholesterol levels ( 33339817) Lung cancer in ever smokers ( 28604730) Lung function (FEV1) ( 28166213) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphoma ( 23349640) Mild influenza (H1N1) infection ( 26379185) Mosquito bite size ( 28199695) Multiple sclerosis (OCB status) ( 23472185) Myositis ( 26291516) Narcolepsy ( 20711174) Peanut allergy ( 25710614) Pulmonary function (smoking interaction) ( 23284291) Red blood cell count ( 29403010) Response to hepatitis B vaccine ( 29534301) Rheumatoid arthritis ( 24782177 18668548 23918589) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Severe aplastic anemia ( 32004448) Sjögren's syndrome ( 28076899) Systemic lupus erythematosus ( 24871463 21408207 23053960) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) Total cholesterol levels ( 33339817) Type 1 diabetes (age at diagnosis) ( 33179336) Type 2 diabetes ( 22693455) Ulcerative colitis ( 28067908) Vasculitis associated with antineutrophil cytoplasmic antibody reactive to myeloperoxidase ( 28029757) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		5 novel interacting genes: CD4 HLA-DQA1 HLA-DQB1 INS LHFPL5
Interacting Genes		5 interacting genes: CD4 HLA-DQA1 HLA-DQB1 INS LHFPL5
Entrez ID		3118
HPRD ID		09982
Ensembl ID		ENSG00000237541
Uniprot IDs		P01906 Q76NI6
PDB IDs
Enriched GO Terms of Interacting Partners?		MHC Class II Protein Complex Binding Clathrin-coated Endocytic Vesicle Membrane MHC Class II Receptor Activity MHC Class II Protein Complex Peptide Antigen Assembly With MHC Class II Protein Complex Regulation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Peptide Antigen Binding Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Antigen Processing And Presentation Of Exogenous Antigen Transport Vesicle Membrane Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation ER To Golgi Transport Vesicle Membrane Antigen Processing And Presentation Of Peptide Antigen Endocytic Vesicle Membrane Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Interleukin-16 Binding Interleukin-16 Receptor Activity Helper T Cell Enhancement Of Adaptive Immune Response Regulation Of Immune System Process Antigen Processing And Presentation Positive Regulation Of Multicellular Organismal Process Trans-Golgi Network Membrane Golgi Membrane Regulation Of Cell Activation Positive Regulation Of Immune Response Response To Methamphetamine Hydrochloride Negative Regulation Of Glycogen Catabolic Process Immune System Process Late Endosome Membrane Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cell Adhesion Immunoglobulin Binding Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Dendritic Spine Maintenance MHC Class II Protein Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction
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