ACACA

Description		acetyl-CoA carboxylase alpha
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GO Annotations	Cellular Component	Fibrillar Center Cytoplasm Mitochondrion Cytosol Actin Cytoskeleton
	Molecular Function	Nucleotide Binding Catalytic Activity Acetyl-CoA Carboxylase Activity Protein Binding ATP Binding Ligase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Tissue Homeostasis Acetyl-CoA Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Acyl-CoA Metabolic Process Lipid Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Protein Homotetramerization Lipid Homeostasis Cellular Response To Prostaglandin E Stimulus Malonyl-CoA Biosynthetic Process
Pathways		ChREBP activates metabolic gene expression Biotin transport and metabolism Carnitine shuttle Activation of gene expression by SREBF (SREBP) Defective HLCS causes multiple carboxylase deficiency Fatty acyl-CoA biosynthesis
Drugs		Biotin
Diseases
GWAS		Daytime nap ( 33568662) Ovarian cancer ( 23535730)
Novel Interacting Genes		16 novel interacting genes: APOC1 ATXN1 BRCA1 CHGB CSNK2A1 CSNK2A2 FGF14 MPHOSPH9 NEIL3 PRKAA1 PRKAA2 PRKAB1 PRKAG1 TRIB1 TRIB2 TRIB3
Interacting Genes		16 interacting genes: APOC1 ATXN1 BRCA1 CHGB CSNK2A1 CSNK2A2 FGF14 MPHOSPH9 NEIL3 PRKAA1 PRKAA2 PRKAB1 PRKAG1 TRIB1 TRIB2 TRIB3
Entrez ID		31
HPRD ID		01938
Ensembl ID		ENSG00000278540
Uniprot IDs		Q13085 Q7Z5W8
PDB IDs		2YL2 3COJ 4ASI 6G2D 6G2H 6G2I 8XKZ 8XL0 8XL1 8XL2
Enriched GO Terms of Interacting Partners?		Nucleotide-activated Protein Kinase Complex Ubiquitin-protein Transferase Regulator Activity AMP-activated Protein Kinase Activity Fatty Acid Biosynthetic Process Mitogen-activated Protein Kinase Kinase Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Small Molecule Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Regulation Of Phosphorus Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Regulation Of Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Lipid Metabolic Process Carboxylic Acid Biosynthetic Process Protein Kinase CK2 Complex Protein Kinase Activity Protein Localization To Lipid Droplet Fatty Acid Metabolic Process Negative Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Catabolic Process Protein Kinase Inhibitor Activity Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Translational Initiation Negative Regulation Of Tubulin Deacetylation CAMP-dependent Protein Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process Cellular Response To Glucose Starvation Negative Regulation Of Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Autophagy Regulation Of Tubulin Deacetylation Regulation Of Glycolytic Process Lipid Droplet Disassembly Regulation Of Proteolysis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Lipid Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MAP Kinase Activity Cellular Response To Stress Negative Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Phosphatidylethanolamine Biosynthetic Process Small Molecule Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of ATP Metabolic Process Regulation Of Protein Deacetylation
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