HGD

Description		homogentisate 1,2-dioxygenase
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome
	Molecular Function	Homogentisate 1,2-dioxygenase Activity Protein Binding Oxidoreductase Activity Identical Protein Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Amino Acid Metabolic Process L-phenylalanine Catabolic Process Tyrosine Metabolic Process L-tyrosine Catabolic Process
Pathways		Tyrosine catabolism
Drugs
Diseases		Alkaptonuria
GWAS
Novel Interacting Genes		6 novel interacting genes: ACSL6 CLDN7 GIT2 NTAQ1 PCDHGC3 TERF1
Interacting Genes		6 interacting genes: ACSL6 CLDN7 GIT2 NTAQ1 PCDHGC3 TERF1
Entrez ID		3081
HPRD ID		06315
Ensembl ID		ENSG00000113924
Uniprot IDs		B3KW64 Q93099
PDB IDs		1EY2 1EYB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein-N-terminal Asparagine Amidohydrolase Activity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Establishment Of Protein Localization To Chromosome Nuclear Telomere Cap Complex Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Telomere Localization Shelterin Complex Meiotic Telomere Clustering Telomeric D-loop Disassembly Ankyrin Repeat Binding Double-stranded Telomeric DNA Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation G-rich Strand Telomeric DNA Binding T-circle Formation Telomeric Loop Disassembly Telomere Capping Arachidonate-CoA Ligase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Synaptic Vesicle Recycling Long-chain Fatty Acid-CoA Ligase Activity DNA Binding, Bending Regulation Of ARF Protein Signal Transduction Long-chain Fatty-acyl-CoA Biosynthetic Process Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Apicolateral Plasma Membrane Negative Regulation Of DNA Replication RNA-templated DNA Biosynthetic Process Long-chain Fatty-acyl-CoA Metabolic Process
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