HELLS

Description		helicase, lymphoid specific
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Pericentric Heterochromatin Site Of Double-strand Break
	Molecular Function	Nucleotide Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Chromatin-protein Adaptor Activity ATP-dependent Chromatin Remodeler Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Urogenital System Development Kidney Development Double-strand Break Repair Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Apoptotic Process Heterochromatin Formation Pericentric Heterochromatin Formation Negative Regulation Of Apoptotic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Lymphocyte Proliferation Cell Division Chromosomal DNA Methylation Maintenance Following DNA Replication Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		TGFBR3 expression
Drugs
Diseases
GWAS		Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Red cell distribution width ( 32888494) Response to (pegylated) interferon in chronic hepatitis B ( 30715261) Serum alkaline phosphatase levels ( 33547301) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Novel Interacting Genes		11 novel interacting genes: APP CEBPA DNMT1 DNMT3B E2F3 GPAT4-AS1 GTSF1L HDAC1 MEOX2 SERTAD2 USP11
Interacting Genes		11 interacting genes: APP CEBPA DNMT1 DNMT3B E2F3 GPAT4-AS1 GTSF1L HDAC1 MEOX2 SERTAD2 USP11
Entrez ID		3070
HPRD ID		07232
Ensembl ID		ENSG00000119969
Uniprot IDs		A0A087WSW7 A0A0B4J1V9 Q0VGL2 Q76H82 Q9NRZ9
PDB IDs		8SKZ
Enriched GO Terms of Interacting Partners?		DNA-methyltransferase Activity DNA (cytosine-5-)-methyltransferase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Chromatin Binding Positive Regulation Of DNA-templated Transcription Regulation Of Smooth Muscle Cell Apoptotic Process DNA Methylation-dependent Constitutive Heterochromatin Formation Amyloid-beta Complex Growth Cone Lamellipodium Epigenetic Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Positive Regulation Of Gene Expression Amylin Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Heterochromatin Constitutive Heterochromatin Formation DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Transcription Corepressor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Muscle Cell Differentiation Promoter-specific Chromatin Binding Acetylcholine Receptor Activator Activity Negative Regulation Of RNA Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Response To Vitamin B2 C/EBP Complex Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Chromosomal DNA Methylation Maintenance Following DNA Replication Krueppel-associated Box Domain Binding Positive Regulation Of Smooth Muscle Cell Proliferation PTB Domain Binding
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