HCRTR2

Description		hypocretin receptor 2
Image
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Membrane Synapse
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity Orexin Receptor Activity Peptide Hormone Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Circadian Sleep/wake Cycle, Wakefulness Circadian Sleep/wake Cycle Process Cellular Response To Hormone Stimulus Locomotion Regulation Of Cytosolic Calcium Ion Concentration
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs		Suvorexant Lemborexant Daridorexant
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Blood urea nitrogen levels ( 31152163) Chronotype ( 27494321 30696823) Daytime nap ( 33568662) Excessive daytime sleepiness ( 27992416) Fasting glucose change (long-term) ( 31263163) HIV-1 control ( 20041166) Menarche (age at onset) ( 25231870) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600 27494321) Severity of nausea and vomiting of pregnancy ( 29563502) Sleep duration (short sleep) ( 30846698) Sleep traits (multi-trait analysis) ( 27992416)
Novel Interacting Genes		3 novel interacting genes: CD200 HCRT TFAP2B
Interacting Genes		3 interacting genes: CD200 HCRT TFAP2B
Entrez ID		3062
HPRD ID		08374
Ensembl ID		ENSG00000137252
Uniprot IDs		O43614 S4X0W3
PDB IDs		4S0V 5WQC 5WS3 6TPG 6TPJ 6TPN 7L1U 7L1V 7SQO 7SR8 7XRR
Enriched GO Terms of Interacting Partners?		Regulation Of Secretion Regulation Of Secretion By Cell Type 1 Orexin Receptor Binding Type 2 Orexin Receptor Binding Positive Regulation Of Transmission Of Nerve Impulse Neuronal Dense Core Vesicle Lumen Regulation Of Transport Negative Regulation Of Transmission Of Nerve Impulse Sleep Regulation Of Protein Secretion Protein Binding Involved In Heterotypic Cell-cell Adhesion Negative Regulation Of T Cell Migration Glycosylated Region Protein Binding Negative Regulation Of Matrix Metallopeptidase Secretion Distal Tubule Development Metanephric Nephron Development Ductus Arteriosus Closure Negative Regulation Of Transport Regulation Of Matrix Metallopeptidase Secretion Regulation Of Protein Transport Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Lymphocyte Migration Regulation Of Establishment Of Protein Localization Negative Regulation Of Macrophage Migration Negative Regulation Of Macrophage Activation Negative Regulation Of Neuroinflammatory Response Nephron Development Sympathetic Nervous System Development Collecting Duct Development Negative Regulation Of Nervous System Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Production Smooth Muscle Tissue Development Nephron Tubule Development Negative Regulation Of DNA Replication Negative Regulation Of Metabolic Process Aorta Morphogenesis Renal Tubule Development Neuropeptide Hormone Activity Negative Regulation Of Potassium Ion Transport Negative Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Activation Retina Layer Formation Rough Endoplasmic Reticulum Eating Behavior Temperature Homeostasis Cell-cell Adhesion Mediator Activity Negative Regulation Of Mononuclear Cell Migration Heterotypic Cell-cell Adhesion Hindlimb Morphogenesis
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