TBX21

Description		T-box transcription factor 21
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Neuronal Cell Body
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification T-helper 1 Cell Lineage Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Virus Positive Regulation Of Gene Expression T Cell Differentiation Negative Regulation Of Interleukin-2 Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of T Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Lymphocyte Migration Negative Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of T-helper 17 Cell Lineage Commitment Negative Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of T-helper 1 Cell Cytokine Production
Pathways		Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Asthma ( 34103634 31619474 30929738) Asthma (childhood onset) ( 31036433) Autoimmune thyroid disease ( 32581359) Body mass index ( 28448500 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically inactive individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Diverticular disease ( 30177863) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Multiple sclerosis ( 22190364) Simvastatin-induced myopathy ( 31220337)
Novel Interacting Genes		3 novel interacting genes: EXOC5 HOXC11 ZNF490
Interacting Genes		3 interacting genes: EXOC5 HOXC11 ZNF490
Entrez ID		30009
HPRD ID		05355
Ensembl ID		ENSG00000073861
Uniprot IDs		Q9UL17
PDB IDs
Enriched GO Terms of Interacting Partners?
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