DMGDH

Description		dimethylglycine dehydrogenase
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	RNA Binding Electron Transfer Activity Oxidoreductase Activity Dimethylglycine Dehydrogenase Activity
	Biological Process	Amino-acid Betaine Catabolic Process Choline Metabolic Process Choline Catabolic Process
Pathways		Choline catabolism
Drugs
Diseases		Dimethylglycine dehydrogenase deficiency (DMGDHD)
GWAS		Betaine levels in individuals undergoing cardiac evaluation ( 26822151) Blood and toenail selenium levels ( 25343990) Blood trace element (Se levels) ( 23720494) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Estimated glomerular filtration rate ( 31152163) HDL cholesterol levels ( 32203549) Plasma selenium concentration ( 33382417) Salivary metabolite levels ( 31960908) Serum metabolite levels ( 33031748) Toenail selenium levels ( 25343990) Triglyceride levels ( 32154731 32203549) Type 2 diabetes ( 30297969) Urinary metabolites ( 26352407)
Novel Interacting Genes		1 novel interacting genes: RNF10
Interacting Genes		1 interacting genes: RNF10
Entrez ID		29958
HPRD ID		05789
Ensembl ID		ENSG00000132837
Uniprot IDs		B3KQ84 Q9UI17
PDB IDs		5L46
Enriched GO Terms of Interacting Partners?		Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Positive Regulation Of Myelination Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Regulation Of Myelination Postsynaptic Signal Transduction Protein Monoubiquitination Protein Autoubiquitination Regulation Of Gliogenesis Cytosolic Ribosome Regulation Of Nervous System Process Negative Regulation Of Nervous System Development Negative Regulation Of Neurogenesis
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