EEF2K

Description		eukaryotic elongation factor 2 kinase
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GO Annotations	Cellular Component	Cytoplasm Cytosol Postsynaptic Density Dendritic Spine Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Elongation Factor-2 Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding Translation Factor Activity, RNA Binding Kinase Activity Transferase Activity
	Biological Process	Response To Ischemia Translational Elongation Myosin II Filament Disassembly Cellular Response To Insulin Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Protein Autophosphorylation Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Anoxia Regulation Of Translation At Postsynapse Cellular Response To Brain-derived Neurotrophic Factor Stimulus Response To Prolactin
Pathways		mTORC1-mediated signalling
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549)
Novel Interacting Genes		17 novel interacting genes: CDK1 EEF2 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 PRKAA1 PRKAA2 PRKACA RPS6KA1 RPS6KB1 RPS6KB2
Interacting Genes		17 interacting genes: CDK1 EEF2 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 PRKAA1 PRKAA2 PRKACA RPS6KA1 RPS6KB1 RPS6KB2
Entrez ID		29904
HPRD ID		07369
Ensembl ID		ENSG00000103319
Uniprot IDs		A0AAG2TFE4 O00418
PDB IDs		5J8H 5KS5 6NX4 7SHQ 8FNY 8FO6 8GM4 8GM5
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Nucleotide Binding ATP Binding Transferase Activity Intracellular Signal Transduction MAP Kinase Activity MAPK Cascade Intracellular Signaling Cassette Post-transcriptional Regulation Of Gene Expression TORC1 Signaling Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Signal Transduction Positive Regulation Of Metabolic Process Protein Localization To Lipid Droplet Cellular Senescence Regulation Of TOR Signaling Stress-activated MAPK Cascade Response To Reactive Oxygen Species Stress-activated Protein Kinase Signaling Cascade Calcium-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Protein Phosphorylation Nucleoplasm Response To Oxidative Stress Cellular Response To Oxidative Stress Cellular Response To Oxygen-containing Compound Phosphorylation Nucleus Cellular Response To Reactive Oxygen Species Regulation Of Circadian Rhythm Regulation Of Translation Cytosol Protein Metabolic Process Positive Regulation Of Translational Initiation Nucleotide-activated Protein Kinase Complex Cellular Response To Chemical Stress Response To Nutrient Levels Cytoplasm Regulation Of Gene Expression Response To Stress Regulation Of Protein Metabolic Process
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