GRM8

Description		glutamate metabotropic receptor 8
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GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Group III Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Glutamate Receptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Visual Perception Regulation Of Synaptic Transmission, Glutamatergic
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		Glutamic acid
Diseases
GWAS		Anti-saccade response ( 25387707 29064472) Anxiety ( 33859377) Carotid atherosclerosis in HIV infection ( 20009918) Chemerin levels ( 20237162) Creutzfeldt-Jakob disease (sporadic) ( 25918841) Depression (quantitative trait) ( 20800221) Experiencing mood swings ( 29500382) Fasting glucose change (long-term) ( 31263163) Feeling hurt ( 29500382) Feeling worry ( 29500382) Gastroesophageal reflux disease ( 31527586 34187846) General factor of neuroticism ( 30867560) Hearing function ( 25060954) Hip circumference adjusted for BMI ( 28552196) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Neurociticism ( 29500382) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Smoking initiation ( 30617275) Type 2 diabetes ( 32499647) Worry too long after an embarrassing experience ( 29500382) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Novel Interacting Genes		5 novel interacting genes: DNAJC5 FLNA GPRASP1 PIAS1 PIAS2
Interacting Genes		5 interacting genes: DNAJC5 FLNA GPRASP1 PIAS1 PIAS2
Entrez ID		2918
HPRD ID		03071
Ensembl ID		ENSG00000179603
Uniprot IDs		A0A9L9PYG5 O00222
PDB IDs		6BSZ 6BT5 6E5V
Enriched GO Terms of Interacting Partners?		SUMO Ligase Activity SUMO Transferase Activity Protein Sumoylation Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential PML Body Transcription Coregulator Activity G Protein-coupled Receptor Catabolic Process Glycoprotein Ib-IX-V Complex Fc-gamma Receptor I Complex Binding Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Formation Of Radial Glial Scaffolds DNA-binding Transcription Factor Binding Tubulin Deacetylation Negative Regulation Of Apoptotic Process Myb Complex Establishment Of Sertoli Cell Barrier Transcription Corepressor Activity Protein Localization To Bicellular Tight Junction Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential ATP-dependent Protein Binding Blood Coagulation, Intrinsic Pathway Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Chromaffin Granule Membrane Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Transcription By RNA Polymerase I Ubiquitin Protein Ligase Binding Positive Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Platelet Activation Protein Deacetylation Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Sumoylation
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