GRM4

Description		glutamate metabotropic receptor 4
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Cytoplasmic Vesicle Synapse Presynapse
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Glutamate Receptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Neurotransmitter Secretion Positive Regulation Of MAPK Cascade Regulation Of Neuron Apoptotic Process Regulation Of Synaptic Transmission, Glutamatergic
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs		Glutamic acid
Diseases
GWAS		A body shape index ( 34021172) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Appendicular lean mass ( 33097823) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) BMI at birth ( 31575865) Body mass index ( 26426971 28892062) Childhood body mass index ( 33045005) HDL levels x fish oil supplementation interaction (2df) ( 33760818) Height ( 34054925) Hip circumference adjusted for BMI ( 34021172) Inflammatory skin disease ( 25574825) Monocyte count ( 32888494) Osteosarcoma ( 23727862) Pulse pressure ( 30578418) Regular attendance at a gym or sports club ( 29970889) Tonsillectomy ( 28928442 27182965) Uterine fibroids ( 31649266) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Weight ( 34054925)
Novel Interacting Genes		5 novel interacting genes: ANK3 CALM1 FLNA GNA15 GNAQ
Interacting Genes		5 interacting genes: ANK3 CALM1 FLNA GNA15 GNAQ
Entrez ID		2914
HPRD ID		04978
Ensembl ID		ENSG00000124493
Uniprot IDs		A1L4F9 A8K0J8 B7ZLU9 Q14833
PDB IDs		7E9H 8JD4 8JD5 8JD6 8WG9 8WGB 8WGC 8WGD
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Binding Transmembrane Transporter Binding Regulation Of Cell Communication By Electrical Coupling G Protein-coupled Acetylcholine Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Negative Regulation Of Transporter Activity G Protein-coupled Receptor Signaling Pathway Regulation Of Monoatomic Cation Transmembrane Transport Heterotrimeric G-protein Complex Regulation Of Monoatomic Ion Transmembrane Transport Acetylcholine Receptor Signaling Pathway Regulation Of Metal Ion Transport Postsynaptic Signal Transduction Regulation Of Platelet Activation Regulation Of Action Potential Regulation Of Monoatomic Ion Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Potassium Ion Transport Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Protein Location In Plasma Membrane Regulation Of Sequestering Of Calcium Ion Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Z Disc Positive Regulation Of Cell Communication By Electrical Coupling Fc-gamma Receptor I Complex Binding Tubulin Deacetylation Myb Complex Signal Transduction Calcium-mediated Signaling Positive Regulation Of Monoatomic Ion Transport Formation Of Radial Glial Scaffolds Establishment Of Sertoli Cell Barrier Protein Localization To Plasma Membrane Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Plasma Membrane Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Glycoprotein Ib-IX-V Complex
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