DROSHA

Description		drosha ribonuclease III
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Organelle Microprocessor Complex Glutamatergic Synapse
	Molecular Function	Lipopolysaccharide Binding RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Ribonuclease III Activity Protein Binding Hydrolase Activity DEAD/H-box RNA Helicase Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding R-SMAD Binding Primary MiRNA Binding
	Biological Process	RRNA Processing RNA Processing Regulation Of Gene Expression MiRNA Metabolic Process Positive Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing Primary MiRNA Processing Pre-miRNA Processing MiRNA Processing Ribosome Biogenesis Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Regulation Of MiRNA Metabolic Process
Pathways		MicroRNA (miRNA) biogenesis
Drugs
Diseases
GWAS		Cerebrospinal fluid t-tau levels in Alzheimer's disease dementia ( 29274321) Height ( 33713608) Lung function (FEV1) ( 26635082) Tuberculosis ( 30713548)
Novel Interacting Genes		6 novel interacting genes: DGCR8 DYRK1A RNF10 SP1 TULP3 ZNF512B
Interacting Genes		6 interacting genes: DGCR8 DYRK1A RNF10 SP1 TULP3 ZNF512B
Entrez ID		29102
HPRD ID		10196
Ensembl ID		ENSG00000113360
Uniprot IDs		Q9NRR4
PDB IDs		2KHX 2NA2 5B16 6LXD 6LXE 6V5B 6V5C 9ASM 9ASN 9ASO 9ASP 9ASQ
Enriched GO Terms of Interacting Partners?		Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Amyloid-beta Formation Regulation Of Amide Metabolic Process Regulation Of Gene Expression Histone H3T45 Kinase Activity Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Response To Wortmannin Bronchus Morphogenesis Microprocessor Complex Positive Regulation Of Pre-miRNA Processing Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Intraciliary Transport Particle A Binding Regulation Of RNA Metabolic Process Negative Regulation Of Heterochromatin Formation Regulation Of Metabolic Process Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Protein-RNA Adaptor Activity Positive Regulation Of MiRNA Processing Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Cellular Response To Zinc Ion Starvation Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Regulation Of Heterochromatin Formation Neural Tube Formation Embryonic Neurocranium Morphogenesis Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation Primary MiRNA Binding Rhythmic Process Transcription Cis-regulatory Region Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity 9+0 Non-motile Cilium Neurofilament Dorsal/ventral Neural Tube Patterning Positive Regulation Of MiRNA-mediated Gene Silencing Primary MiRNA Processing Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Development Regulation Of MiRNA Processing
Tagcloud ?