MACROD1

Description		mono-ADP ribosylhydrolase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Deacetylase Activity O-acetyl-ADP-ribose Deacetylase Activity ADP-ribosylglutamate Hydrolase Activity
	Biological Process	DNA Damage Response Purine Nucleoside Metabolic Process Protein De-ADP-ribosylation Peptidyl-glutamate ADP-deribosylation
Pathways
Drugs
Diseases
GWAS		A body shape index ( 34021172) Bipolar disorder ( 31043756) Body mass index ( 25673413) Body mass index and HDL-C (pairwise) ( 33619380) Body mass index and triglycerides (pairwise) ( 33619380) Fasting insulin ( 34059833) Fruit consumption ( 32066663) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817) Hip circumference adjusted for BMI ( 34021172 25673412) Hip index ( 34021172) Immature fraction of reticulocytes ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Serum uric acid levels ( 32514006) Triacylglycerol 56:6 levels ( 31560688) Triglyceride levels ( 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		4 interacting genes: EPB41 IKBKG KPNA1 UXT
Entrez ID		28992
HPRD ID		17448
Ensembl ID		ENSG00000133315
Uniprot IDs		A0A6Q8PH91 Q9BQ69
PDB IDs		2X47 6LH4
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Protein-containing Complex Satellite Cell Activation Involved In Skeletal Muscle Regeneration Spindle Pole Linear Polyubiquitin Binding Positive Regulation Of Protein Localization To Cell Cortex Postsynapse To Nucleus Signaling Pathway Skeletal Muscle Satellite Cell Proliferation Skeletal Muscle Satellite Cell Activation Establishment Of Organelle Localization Regulation Of Protein Localization To Cell Cortex Spectrin-associated Cytoskeleton Skeletal Muscle Cell Proliferation Establishment Of Localization In Cell NLS-dependent Protein Nuclear Import Complex RPAP3/R2TP/prefoldin-like Complex Transferrin Receptor Binding Anoikis IkappaB Kinase Complex Regulation Of Intestinal Absorption 1-phosphatidylinositol Binding
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