RGCC

Description		regulator of cell cycle
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton
	Molecular Function	Protein Binding Kinase Activator Activity Protein Kinase Regulator Activity Protein Kinase Binding Protein Kinase Activator Activity R-SMAD Binding
	Biological Process	Negative Regulation Of Exit From Mitosis Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Negative Regulation Of Endothelial Cell Proliferation Complement Receptor Mediated Signaling Pathway Positive Regulation Of Extracellular Matrix Constituent Secretion Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Angiogenesis Positive Regulation Of Collagen Biosynthetic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Cellular Response To Hypoxia Fibroblast Activation Negative Regulation Of Fibroblast Growth Factor Production Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Multiple sclerosis ( 31604244) Pre-treatment viral load in HIV-1 infection ( 31219150)
Novel Interacting Genes		3 novel interacting genes: AKT1 CDK1 PLK1
Interacting Genes		3 interacting genes: AKT1 CDK1 PLK1
Entrez ID		28984
HPRD ID		17970
Ensembl ID		ENSG00000102760
Uniprot IDs		Q9H4X1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Localization To Nucleus Regulation Of Protein Localization To Nucleus Mitotic Nuclear Membrane Disassembly Spindle Membrane Disassembly Nuclear Membrane Disassembly Peptidyl-threonine Phosphorylation Protein Localization To Site Of Double-strand Break Protein Serine Kinase Activity Protein Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Phosphorylation Protein Serine/threonine Kinase Activity Mitotic G2 DNA Damage Checkpoint Signaling Chromosome Condensation Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Localization Spindle Microtubule Peptidyl-serine Phosphorylation Regulation Of DNA Metabolic Process Positive Regulation Of Organ Growth Regulation Of Mitotic Cell Cycle Protein Kinase Activity Nuclear Membrane Organization Centrosome Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Cell Cycle G2/M Phase Transition Protein Localization To Organelle Membrane Organization Kinase Activity Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Microtubule Organizing Center Organization Regulation Of Cell Cycle Process Regulation Of Organ Growth Positive Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Post-translational Protein Modification Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Localization To Chromosome Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteasomal Protein Catabolic Process
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