GRIA4

Description		glutamate ionotropic receptor AMPA type subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Cell Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Postsynaptic Density Membrane Extracellular Vesicle
	Molecular Function	Amyloid-beta Binding Glutamate-gated Receptor Activity AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Monoatomic Ion Transmembrane Transport Negative Regulation Of Smooth Muscle Cell Apoptotic Process Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Regulation Of Presynaptic Membrane Potential
Pathways		Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules
Drugs		Glutamic acid Butabarbital Ethanol Talampanel CX-717 Fluciclovine (18F)
Diseases
GWAS		Age at first sexual intercourse ( 27089180 34211149) Glioma ( 34319593) Myopia ( 27182965) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Post bronchodilator FEV1 ( 26634245) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Novel Interacting Genes		13 novel interacting genes: ABHD5 ACTN1 CACNG2 CAMK2G EPB41L1 GRIA1 GRIP1 IQGAP1 PICK1 PRKACA PRKCA PRKCG SDCBP
Interacting Genes		13 interacting genes: ABHD5 ACTN1 CACNG2 CAMK2G EPB41L1 GRIA1 GRIP1 IQGAP1 PICK1 PRKACA PRKCA PRKCG SDCBP
Entrez ID		2893
HPRD ID		00694
Ensembl ID		ENSG00000152578
Uniprot IDs		A0A8D9PH77 A0A994J6J2 G3V164 P48058 Q1WWK6
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuron Projection Endocytic Vesicle Membrane Postsynaptic Density Modulation Of Chemical Synaptic Transmission Synapse Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Synaptic Transmission Regulation Of Transport Response To Psychosocial Stress Cytosol Long-term Synaptic Potentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell-cell Junction Regulation Of Synaptic Plasticity Plasma Membrane Protein Domain Specific Binding Regulation Of Vesicle-mediated Transport Regulation Of Secretion By Cell Somatodendritic Compartment Response To Morphine Response To Peptide Hormone Long-term Synaptic Depression Response To Toxic Substance Regulation Of Secretion Regulation Of Endocytosis Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine Kinase Activity Intracellular Signal Transduction Regulation Of Cell Communication Establishment Of Protein Localization Protein Serine/threonine Kinase Activity Regulation Of Biological Quality Regulation Of Signaling AMPA Glutamate Receptor Complex Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Insulin Secretion Protein Localization To Postsynaptic Membrane Intracellular Signaling Cassette Protein Localization To Postsynapse Cell Junction Organization Regulation Of Exocytosis Regulation Of Protein Localization Negative Regulation Of Synaptic Transmission Regulation Of Peptide Hormone Secretion Actin Filament Binding Protein Kinase Activity Establishment Of Protein Localization To Membrane Postsynapse Organization Regulation Of Hormone Levels
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