GRIA3

Description		glutamate ionotropic receptor AMPA type subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Dendritic Spine Synapse Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Postsynaptic Density Membrane
	Molecular Function	Amyloid-beta Binding Glutamate-gated Receptor Activity AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Protein Homotetramerization Protein Heterotetramerization Regulation Of Postsynaptic Membrane Potential Long-term Synaptic Potentiation Regulation Of Presynaptic Membrane Potential
Pathways		Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules
Drugs		Glutamic acid Butabarbital Ethanol Lithium cation Aniracetam Talampanel CX-717 Fluciclovine (18F) Lithium citrate Lithium succinate Lithium carbonate
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Mortality in sepsis ( 27639821)
Novel Interacting Genes		13 novel interacting genes: ADRB2 CREBBP GRIA2 GRIP1 GRIP2 GZMB LYN NSF PICK1 PPM1G SDCBP SQSTM1 TSPAN7
Interacting Genes		13 interacting genes: ADRB2 CREBBP GRIA2 GRIP1 GRIP2 GZMB LYN NSF PICK1 PPM1G SDCBP SQSTM1 TSPAN7
Entrez ID		2892
HPRD ID		02378
Ensembl ID		ENSG00000125675
Uniprot IDs		P42263 Q17R51 Q5XKG2
PDB IDs
Enriched GO Terms of Interacting Partners?		Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Endocytic Vesicle Membrane Establishment Of Protein Localization Postsynaptic Specialization, Intracellular Component Establishment Of Protein Localization To Membrane Localization Within Membrane Establishment Of Protein Localization To Plasma Membrane Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Intracellular Protein Transport Cellular Localization Establishment Of Localization In Cell Endosome To Plasma Membrane Protein Transport Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Neurotransmitter Receptor Transport Protein Localization To Membrane Protein Transport Vesicle-mediated Transport Protein-containing Complex Binding Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Signal Transduction Intracellular Transport Vesicle-mediated Transport To The Plasma Membrane Regulation Of Biological Quality Ionotropic Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Binding Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Regulation Of Toll-like Receptor 4 Signaling Pathway Innate Immune Response-activating Signaling Pathway Temperature Homeostasis Lysosome Multicellular Organismal-level Homeostasis Regulation Of Protein Localization Regulation Of Exocytosis Protein Localization To Plasma Membrane Modulation Of Chemical Synaptic Transmission Synapse Ligand-gated Ion Channel Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Protein Sequestering Activity Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Protein Localization To Cell Periphery
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