SH3PXD2B

Description		SH3 and PX domains 2B
Image		No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Cell Projection Anchoring Junction
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding SH2 Domain Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Skeletal System Development Eye Development Superoxide Metabolic Process Heart Development Extracellular Matrix Disassembly Cell Differentiation Superoxide Anion Generation Bone Development Adipose Tissue Development Podosome Assembly Protein Localization To Membrane
Pathways
Drugs
Diseases
GWAS		Body mass index (change over time) ( 25133637) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Menopause (age at onset) ( 26414677) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Weight ( 28552196)
Novel Interacting Genes		1 novel interacting genes: FASLG
Interacting Genes		1 interacting genes: FASLG
Entrez ID		285590
HPRD ID		18591
Ensembl ID		ENSG00000174705
Uniprot IDs		A1X283 G3V144
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phospholipid Translocation Cytoplasmic Vesicle Lumen Retinal Cell Programmed Cell Death Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Inflammatory Cell Apoptotic Process Necroptotic Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Positive Regulation Of Phospholipid Transport Intracellular Chloride Ion Homeostasis Endosomal Lumen Acidification Regulation Of Plasma Membrane Organization Death Receptor Binding Necroptotic Process Chloride Ion Homeostasis Programmed Necrotic Cell Death Programmed Cell Death Involved In Cell Development Monoatomic Anion Homeostasis Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway T Cell Apoptotic Process Tumor Necrosis Factor Receptor Binding Positive Regulation Of ERBB Signaling Pathway Lymphocyte Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Membrane Lipid Distribution Leukocyte Apoptotic Process Regulation Of Endothelial Cell Apoptotic Process Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Intracellular PH Reduction Negative Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Neuron Apoptotic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Caveola Cellular Response To Type II Interferon Positive Regulation Of Lipid Transport Regulation Of Intracellular PH Lysosomal Lumen Regulation Of Cellular PH Calcium Ion Transmembrane Import Into Cytosol Response To Type II Interferon Regulation Of PH Extrinsic Apoptotic Signaling Pathway Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Regulation Of Lipid Transport Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway
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