NKIRAS1

Description		NFKB inhibitor interacting Ras like 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol
	Molecular Function	Nucleotide Binding GTPase Activity GTP Binding GTPase Activating Protein Binding
	Biological Process	Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Ral Protein Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Surfactant Homeostasis Lung Alveolus Development
Pathways		RIP-mediated NFkB activation via ZBP1 TAK1-dependent IKK and NF-kappa-B activation TRAF6 mediated NF-kB activation
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Intake of total sugars ( 31005972) Intelligence (MTAG) ( 29326435)
Novel Interacting Genes		8 novel interacting genes: ACVR1 APP BMPR1B NFKBIA NFKBIB SMURF2 TGFBR1 XRCC2
Interacting Genes		8 interacting genes: ACVR1 APP BMPR1B NFKBIA NFKBIB SMURF2 TGFBR1 XRCC2
Entrez ID		28512
HPRD ID		06841
Ensembl ID		ENSG00000197885
Uniprot IDs		Q9NYS0
PDB IDs
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Activity, Type I SMAD Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus BMP Receptor Activity Activin Receptor Complex Positive Regulation Of Developmental Process Activin Receptor Activity, Type I Regionalization Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Response To Growth Factor Regulation Of Developmental Process Activin Binding Regulation Of Cell Differentiation Pattern Specification Process Regulation Of Apoptotic Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Process Pharyngeal System Development Positive Regulation Of RNA Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Signal Transduction Transforming Growth Factor Beta Binding Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Inflammatory Response Regulation Of Cell Communication Positive Regulation Of Cell Migration Activin Receptor Signaling Pathway Regulation Of RNA Metabolic Process Cellular Response To BMP Stimulus Positive Regulation Of Cell Motility Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signaling Receptor Complex Positive Regulation Of Locomotion Membrane Raft Reproductive Process Defense Response Regulation Of Nucleobase-containing Compound Metabolic Process Ventricular Septum Morphogenesis In Utero Embryonic Development
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