ANGPT2

Description		angiopoietin 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Cell Projection
	Molecular Function	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Metal Ion Binding Receptor Ligand Activity
	Biological Process	Angiogenesis Response To Hypoxia Signal Transduction Germ Cell Development Blood Coagulation Response To Mechanical Stimulus Response To Glucose Gene Expression Negative Regulation Of Cell-substrate Adhesion Response To Activity Negative Regulation Of Angiogenesis Cell Differentiation Negative Regulation Of Blood Coagulation Animal Organ Regeneration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Tie Signaling Pathway Blood Vessel Morphogenesis Positive Regulation Of Coagulation Negative Regulation Of Positive Chemotaxis Positive Regulation Of Multicellular Organismal Process Maternal Process Involved In Female Pregnancy Cellular Response To Growth Factor Stimulus Glomerulus Vasculature Development
Pathways		Tie2 Signaling
Drugs		Vanucizumab Faricimab
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Dental caries (decayed and filled deciduous teeth) ( 31533690) Intraocular pressure ( 29617998 29785010 30054594) Metabolite levels ( 23823483) Response to cytidine analogues (gemcitabine) ( 24483146)
Novel Interacting Genes		6 novel interacting genes: ANGPT1 ANXA7 CDKN1A CSNK2B ITGA5 TEK
Interacting Genes		6 interacting genes: ANGPT1 ANXA7 CDKN1A CSNK2B ITGA5 TEK
Entrez ID		285
HPRD ID		03563
Ensembl ID		ENSG00000091879
Uniprot IDs		O15123
PDB IDs		1Z3S 1Z3U 2GY7 4JZC 4ZFG 8VGP
Enriched GO Terms of Interacting Partners?		Glomerulus Vasculature Development Tie Signaling Pathway Cell-substrate Adhesion Regulation Of Endothelial Cell Migration Sprouting Angiogenesis Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Vascular Permeability Angiogenesis Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Endothelial Cell Apoptotic Process Vasculature Development Regulation Of Locomotion Signaling Receptor Binding Microvillus Regulation Of Programmed Cell Death Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cellular Developmental Process Positive Regulation Of Endothelial Cell Migration Developmental Process Regulation Of Blood Vessel Endothelial Cell Migration PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Integrin Alpha5-beta1 Complex Positive Regulation Of Locomotion Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Blood Vessel Development Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Endothelial Cell Proliferation Integrin Binding Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Cell-substrate Adhesion Alphav-beta3 Integrin-vitronectin Complex Cellular Response To Cell-matrix Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Hemopoiesis Positive Regulation Of Angiogenesis Epithelial Cell Proliferation Positive Regulation Of Vasculature Development Positive Regulation Of Blood-brain Barrier Permeability
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