RSPO1

Description		R-spondin 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Protein Binding Heparin Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Macromolecule Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of FZD by ubiquitination
Drugs
Diseases		46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
GWAS		Axial length ( 24144296) Epithelial ovarian cancer ( 25581431) Eyebrow thickness ( 26926045) Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 29785010 30054594 31959993)
Novel Interacting Genes		2 novel interacting genes: LGR4 ZNRF3
Interacting Genes		2 interacting genes: LGR4 ZNRF3
Entrez ID		284654
HPRD ID		08288
Ensembl ID		ENSG00000169218
Uniprot IDs		Q2MKA7
PDB IDs		4BSO 4BSP 4BSR 4BSS 4BST 4BSU 4CDK 4KNG 4KT1 4LI2 4QXF 8WVU
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Metanephric Glomerulus Development Wnt Receptor Catabolic Process Regulation Of Wnt Signaling Pathway Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Metanephric Nephron Tubule Morphogenesis Negative Regulation Of Non-canonical Wnt Signaling Pathway Intestinal Stem Cell Homeostasis Nephron Tubule Morphogenesis Male Genitalia Development Glomerulus Development Renal Tubule Morphogenesis Bone Remodeling Cell Population Proliferation Protein-hormone Receptor Activity Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Receptor Catabolic Process Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Toll-like Receptor Signaling Pathway Reproductive System Development Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Morphogenesis Of An Epithelium Genitalia Development Regulation Of Kidney Development Regulation Of Toll-like Receptor Signaling Pathway Frizzled Binding Hair Follicle Development Negative Regulation Of Cold-induced Thermogenesis Receptor Metabolic Process Digestive Tract Development Regulation Of Morphogenesis Of A Branching Structure Limb Development Negative Regulation Of Signal Transduction Bone Mineralization Circadian Regulation Of Gene Expression Regulation Of Morphogenesis Of An Epithelium Negative Regulation Of Cell Communication Negative Regulation Of Signaling Hair Cycle Process Stem Cell Proliferation Regulation Of Animal Organ Morphogenesis Tissue Remodeling Biomineral Tissue Development Positive Regulation Of Canonical Wnt Signaling Pathway Epithelial Tube Morphogenesis Cell Surface Receptor Signaling Pathway Osteoblast Differentiation Circadian Rhythm
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