GPR21

Description		G protein-coupled receptor 21
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GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Glucose Homeostasis Negative Regulation Of Insulin Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Novel Interacting Genes		1 novel interacting genes: ATP13A2
Interacting Genes		1 interacting genes: ATP13A2
Entrez ID		2844
HPRD ID		03551
Ensembl ID		ENSG00000188394
Uniprot IDs		B4DSD1 Q99679
PDB IDs		8HIX 8HJ0 8HJ1 8HJ2 8HMV
Enriched GO Terms of Interacting Partners?		Polyamine Transmembrane Transporter Activity Extracellular Vesicle Biogenesis Spermine Transport Extracellular Exosome Biogenesis P-type Ion Transporter Activity Negative Regulation Of Lysosomal Protein Catabolic Process P-type Transmembrane Transporter Activity Regulation Of Autophagosome Size Spermine Transmembrane Transport Cupric Ion Binding ABC-type Polyamine Transporter Activity Polyamine Transmembrane Transport Regulation Of Chaperone-mediated Autophagy Cellular Response To Manganese Ion ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Response To Manganese Ion Autophagosome-lysosome Fusion Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Cellular Response To Zinc Ion Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding Multivesicular Body Membrane Intracellular Zinc Ion Homeostasis Vesicle Membrane Response To Zinc Ion Multivesicular Body Regulation Of Autophagy Of Mitochondrion Autophagosome Membrane Protein Localization To Lysosome Manganese Ion Binding Intracellular Iron Ion Homeostasis Autophagosome Positive Regulation Of Exocytosis Lysosomal Lumen Protein Localization To Vacuole Organelle Membrane Fusion Autophagosome Organization Vesicle Fusion Transport Vesicle Regulation Of Mitochondrion Organization Lysosomal Transport Negative Regulation Of Protein Catabolic Process Organelle Fusion Regulation Of Intracellular Protein Transport Late Endosome Membrane Late Endosome Membrane Fusion Regulation Of Protein Localization To Nucleus
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