GPR18

Description		G protein-coupled receptor 18
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	G Protein-coupled Receptor Activity
	Biological Process	CD8-positive, Alpha-beta Intraepithelial T Cell Differentiation CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Negative Regulation Of Leukocyte Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Phagocytosis
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs		Glycine Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS		Asthma ( 31619474 31959851) Inflammatory bowel disease ( 23128233 28067908)
Novel Interacting Genes		1 novel interacting genes: JUN
Interacting Genes		1 interacting genes: JUN
Entrez ID		2841
HPRD ID		03621
Ensembl ID		ENSG00000125245
Uniprot IDs		Q14330
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Anisomycin Cellular Response To Anisomycin Release From Viral Latency Transcription Factor AP-1 Complex Leading Edge Cell Differentiation Host-mediated Suppression Of Viral Transcription Nuclear Chromosome Eyelid Development In Camera-type Eye Response To Muscle Stretch Negative Regulation Of DNA Binding SMAD Protein Signal Transduction Microglial Cell Activation Neuron Projection Regeneration Host-mediated Suppression Of Viral Proces Axon Regeneration Monocyte Differentiation Host-mediated Perturbation Of Viral Transcription Ubiquitin-like Protein Ligase Binding R-SMAD Binding Host-mediated Activation Of Viral Transcription CAMP Response Element Binding General Transcription Initiation Factor Binding Leukocyte Activation Involved In Inflammatory Response Host-mediated Activation Of Viral Process Integrated Stress Response Signaling Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Response To Axon Injury Axon Development Transcription Repressor Complex Macrophage Activation Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Fibroblast Proliferation Euchromatin JNK Cascade Positive Regulation Of MiRNA Metabolic Process Outflow Tract Morphogenesis Positive Regulation Of MiRNA Transcription Regulation Of DNA Binding Host-mediated Perturbation Of Viral Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of MiRNA Transcription Regulation Of Epithelial Cell Migration Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Cellular Response To Calcium Ion Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of MiRNA Metabolic Process Regulation Of Fibroblast Proliferation Positive Regulation Of Endothelial Cell Proliferation Transforming Growth Factor Beta Receptor Signaling Pathway
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