NEK8

Description		NIMA related kinase 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Cilium Cell Projection Ciliary Inversin Compartment Ciliary Base
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Determination Of Left/right Symmetry Heart Development Animal Organ Morphogenesis Regulation Of Hippo Signaling Animal Organ Development
Pathways
Drugs
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 32888494)
Novel Interacting Genes		11 novel interacting genes: ACVR1 ADAMTSL4 KRTAP13-2 NEK9 OXER1 RGS20 TCF4 TGFBR1 TRIM42 TRIM69 UBC
Interacting Genes		11 interacting genes: ACVR1 ADAMTSL4 KRTAP13-2 NEK9 OXER1 RGS20 TCF4 TGFBR1 TRIM42 TRIM69 UBC
Entrez ID		284086
HPRD ID		14822
Ensembl ID		ENSG00000160602
Uniprot IDs		Q86SG6
PDB IDs
Enriched GO Terms of Interacting Partners?		Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Binding Pharyngeal System Development Transforming Growth Factor Beta Binding Activin Receptor Signaling Pathway Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Growth Factor Binding SMAD Binding Endocardial Cushion Cell Fate Commitment Pigment Cell Development 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Positive Regulation Of Determination Of Dorsal Identity Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Beta-catenin-TCF7L2 Complex Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition BMP Receptor Complex TFIIB-class Transcription Factor Binding Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly Atrial Septum Primum Morphogenesis Endocardial Cushion Fusion Ameboidal-type Cell Migration Protein Kinase Activity Cell Adhesion Involved In Heart Morphogenesis Myofibroblast Differentiation Parathyroid Gland Development Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Extrinsic Apoptotic Signaling Pathway BMP Receptor Activity Cardiac Muscle Cell Fate Commitment Mitral Valve Morphogenesis Positive Regulation Of Mesenchymal Stem Cell Proliferation
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