GNS

Description		glucosamine (N-acetyl)-6-sulfatase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosome Azurophil Granule Lumen Azurophil Granule Lysosomal Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Glycosaminoglycan Binding N-acetylglucosamine-6-sulfatase Activity Sulfuric Ester Hydrolase Activity Hydrolase Activity Sulfate Binding Metal Ion Binding
	Biological Process	Glycosaminoglycan Catabolic Process Heparan Sulfate Proteoglycan Catabolic Process Glycosaminoglycan Metabolic Process Keratan Sulfate Proteoglycan Catabolic Process
Pathways		Keratan sulfate degradation MPS IIID - Sanfilippo syndrome D Lysosome Vesicle Biogenesis Neutrophil degranulation
Drugs
Diseases		Mucopolysaccharidosis type III (MPS3), including: Sanfilippo A syndrome (MPS3A); Sanfilippo B syndrome (MPS3B); Sanfilippo C syndrome (MPS3C); Sanfilippo D syndrome (MPS3D)
GWAS
Novel Interacting Genes		1 novel interacting genes: CDK4
Interacting Genes		1 interacting genes: CDK4
Entrez ID		2799
HPRD ID		09637
Ensembl ID		ENSG00000135677
Uniprot IDs		A0A024RBC5 P15586
PDB IDs
Enriched GO Terms of Interacting Partners?		Cyclin D2-CDK4 Complex Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Cellular Response To Ionomycin Cellular Response To Ether Regulation Of Type B Pancreatic Cell Proliferation Response To Phorbol 13-acetate 12-myristate Cellular Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Interleukin-4 Cyclin Binding Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Response To Interleukin-4 Response To Ether Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cellular Response To Fatty Acid Cyclin-dependent Protein Kinase Holoenzyme Complex Positive Regulation Of Fibroblast Proliferation Response To Fatty Acid Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Fibroblast Proliferation Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Bicellular Tight Junction Positive Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Response To Ketone Transcription Regulator Complex Positive Regulation Of Cell Cycle Process Nuclear Membrane Response To Alcohol Response To Xenobiotic Stimulus Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of Epithelial Cell Proliferation Protein Serine/threonine Kinase Activity
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