GLRB

Description		glycine receptor beta
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Glycine-gated Chloride Channel Complex Dendrite Chloride Channel Complex Cell Projection Synapse Postsynaptic Membrane Glycinergic Synapse GABA-ergic Synapse Postsynaptic Specialization
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Excitatory Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Protein Binding Glycine Binding Extracellularly Glycine-gated Ion Channel Activity Extracellularly Glycine-gated Chloride Channel Activity Protein-containing Complex Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Startle Response Monoatomic Ion Transport Chloride Transport Neuropeptide Signaling Pathway Chemical Synaptic Transmission Acrosome Reaction Nervous System Development Visual Perception Adult Walking Behavior Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Neuromuscular Process Synaptic Transmission, Glycinergic Righting Reflex Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Gamma-aminobutyric Acid Receptor Clustering Chloride Transmembrane Transport
Pathways		Neurotransmitter receptors and postsynaptic signal transmission Neurotransmitter receptors and postsynaptic signal transmission
Drugs		Glycine Lindane Memantine Seletracetam Cannabidiol Medical Cannabis Nabiximols
Diseases		Hyperekplexia
GWAS		Cognitive decline (age-related) ( 28078323) Triglyceride levels x loop diuretics use interaction ( 31806883)
Novel Interacting Genes		2 novel interacting genes: APP GPHN
Interacting Genes		2 interacting genes: APP GPHN
Entrez ID		2743
HPRD ID		11751
Ensembl ID		ENSG00000109738
Uniprot IDs		P48167
PDB IDs		5BKF 5BKG 7KUY 7L31 8DN2 8DN3 8DN4 8DN5
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Signaling Receptor Binding Growth Cone Lamellipodium Synaptic Membrane Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Postsynapse Response To Metal Ion Trans-synaptic Signaling Intermediate-density Lipoprotein Particle Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Synaptic Signaling Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Dendritic Spine Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Synapse Organization Glycine Receptor Clustering Postsynaptic Specialization, Intracellular Component Molybdopterin Cofactor Binding Nitrate Reductase Activity Molybdopterin Cofactor Biosynthetic Process Molybdopterin Adenylyltransferase Activity Establishment Of Synaptic Specificity At Neuromuscular Junction Molybdopterin Cofactor Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Molybdopterin Molybdotransferase Activity Gamma-aminobutyric Acid Receptor Clustering Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity
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