GCLC

Description		glutamate-cysteine ligase catalytic subunit
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Glutamate-cysteine Ligase Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Catalytic Activity Glutamate-cysteine Ligase Activity Protein Binding ATP Binding Glutamate Binding Ligase Activity ADP Binding Protein-containing Complex Binding
	Biological Process	Cysteine Metabolic Process Glutamate Metabolic Process Glutathione Metabolic Process Glutathione Biosynthetic Process Response To Oxidative Stress Response To Nutrient Response To Heat Response To Xenobiotic Stimulus Response To Hormone Response To Activity L-ascorbic Acid Metabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Human Chorionic Gonadotropin Cell Redox Homeostasis Negative Regulation Of DNA-templated Transcription Response To Arsenic-containing Substance Response To Cadmium Ion Response To Nitrosative Stress Regulation Of Mitochondrial Depolarization Response To Interleukin-1 Cellular Response To Mechanical Stimulus Cellular Response To Glucose Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Thyroxine Stimulus Blood Vessel Diameter Maintenance Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Hepatic Stellate Cell Activation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Glutathione synthesis and recycling Defective GCLC causes HAGGSD NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs		Glutamic acid Cysteine
Diseases		Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		Benign prostatic hyperplasia ( 30988330) Birth weight ( 31043758) Daytime sleep phenotypes ( 27126917) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Waist circumference ( 28552196)
Novel Interacting Genes		1 novel interacting genes: CCL22
Interacting Genes		1 interacting genes: CCL22
Entrez ID		2729
HPRD ID		06032
Ensembl ID		ENSG00000001084
Uniprot IDs		E1CEI4 P48506 Q14TF0
PDB IDs
Enriched GO Terms of Interacting Partners?		Eosinophil Migration Eosinophil Chemotaxis CCR Chemokine Receptor Binding Leukocyte Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Granulocyte Migration Myeloid Leukocyte Migration Chemokine Activity Killing Of Cells Of Another Organism Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Antimicrobial Humoral Response Cell Killing Cell Chemotaxis Cytokine Activity Leukocyte Migration Humoral Immune Response
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