GCLC

Description		glutamate-cysteine ligase catalytic subunit
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Glutamate-cysteine Ligase Complex
	Molecular Function	Magnesium Ion Binding Glutamate-cysteine Ligase Activity Protein Binding ATP Binding Glutamate Binding ADP Binding
	Biological Process	Cysteine Metabolic Process Glutamate Metabolic Process Glutathione Biosynthetic Process Response To Oxidative Stress Response To Heat Response To Hormone Negative Regulation Of Apoptotic Process Cell Redox Homeostasis Negative Regulation Of Transcription, DNA-templated Blood Vessel Diameter Maintenance
Pathways		Glutathione synthesis and recycling Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
Drugs		Glutamic acid Cysteine
Diseases		Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		Benign prostatic hyperplasia ( 30988330) Birth weight ( 31043758) Daytime sleep phenotypes ( 27126917) Monocyte percentage of white cells ( 32888494) Waist circumference ( 28552196)
Interacting Genes		1 interacting genes: CCL22
Entrez ID		2729
HPRD ID		06032
Ensembl ID		ENSG00000001084
Uniprot IDs		E1CEI4 P48506 Q14TF0
PDB IDs
Enriched GO Terms of Interacting Partners?
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